Searchable abstracts of presentations at key conferences in endocrinology

ea0070s7.1 | Endocrine disruptors, just a hype or not? | ECE2020

The environment and male fertility, will we disappear?

Giwercman Aleksander

From an evolutionary point of view, reproduction is one of the key events. Thus, any potential threat to human fertility, needs to be taken seriously by researchers as well as the general public. In 1992 a meta-analysis of 63 published papers, indicated almost 50% reduction of sperm counts during the period 1940 to 1990. Since then, the discussion on whether the sperm numbers are decreasing or not has divided the scientific world into believers and non-believers. A concomitant...

ea0020s27.3 | Impact of SNPs on Hormone Function | ECE2009

Estrogen and androgen receptor variants

Giwercman Aleksander

Androgens and oestrogens, are acting through specific receptors, belonging to the nuclear receptor family and both androgen receptor (AR) and the two forms of oestrogen receptor, α (ER1) and β (ER2) are richly expressed in different parts of the male reproductive system.There are several examples indicating that polymorphisms in these sex hormone receptors can be associated with some types of disease or milder dysfunction of the sex hormone reg...

ea0073mte10 | Meet The Expert 10: Outlook for male fertility preservation | ECE2021

Outlook for male fertility preservation

Giwercman Aleksander

Cryopreservation of spermatozoa, has been utilized for decennia as an easily accessible tool in male fertility preservation, prior to treatment for cancer and autoimmune diseases. However, although this technique is well established, there is a number of questions regarding this procedure which still needs to be answered. Which patient groups should be offered semen cryopreservation? Are spermatozoa preserved prior to treatment safer to use for fertilization than fresh, ejacul...

ea0037oc2.4 | Reproduction | ECE2015

Low free testosterone is associated with hypogonadal symptoms in men with normal total testosterone levels: results from the European Male Ageing Study

Antonio Leen , Wu Frederic , O'Neill Terrence , Pye Stephen , Carter Emma , Finn Joseph , Laurent Michael , Huhtaniemi Ilpo , Rutter Martin , Rastrelli Giulia , Forti Gianni , Bartfai Gyorgy , Casanueva Felipe , Kula Krzysztof , Punab Margus , Giwercman Aleksander , Claessens Frank , Decallonne Brigitte , Vanderschueren Dirk

Background: During ageing, total testosterone (TT) declines and SHBG increases, resulting in a greater decline of free testosterone (FT) compared to TT. However, guidelines suggest using TT to diagnose androgen deficiency and to reserve FT only for men with borderline TT. We investigated if isolated low FT or isolated low TT was associated with androgen-related endpoints in healthy men.Methods: 3369 community-dwelling men, aged 40–79, were included....

ea0037gp.08.01 | Reproduction: Male and endocrine disruptors | ECE2015

Characteristics and predictors of primary hypogonadism in ageing men: longitudinal data from the European Male Ageing Study

Ahern Tomas B , Huhtaniemi Ilpo T , Carter Emma L , Finn Joseph D , Pye Stephen R , O'Neill Terence W , Bartfai Gyorgy , Casanueva Felipe F , Forti Gianni , Giwercman Aleksander , Han Thang S , Kula Krzysztof , Lean Michael EJ , Pendleton Neil , Punab Margus , Vanderschueren Dirk , Wu Frederick C W

Introduction: Primary hypogonadism (PHG, testosterone <10.5 nmol/l and LH >9.5 U/l) without a recognisable cause affects ~2% of community-dwelling middle-aged and older men. We sought to identify the clinical significance of, and risk factors for, this apparently age-related hypogonadal state.Methods/design: The European Male Ageing Study (EMAS) is a prospective observational cohort survey of 3.369 community-dwelling men aged 40–79 in eight ...