Searchable abstracts of presentations at key conferences in endocrinology

ea0005oc35 | Thyroid and Calcium | BES2003

Five human thyroid hormone receptor beta1 5'-UTR isoforms differentially regulate levels of gene expression and protein translation in individual tissues

Frankton S , Gleason L , Harvey C , Williams G

In humans only thyroid hormone (T3) receptor (TR) beta1 and beta2 mRNAs have been identified, whereas alternative splicing generates recently characterised beta3 and deltabeta3 transcripts in rat and further N-terminal isoforms in other species. We investigated whether additional transcripts arise from the human TRbeta gene by 5'-RACE. Five distinct TRbeta1 transcripts were isolated, including the previously described TRbeta1 mRNA and four novel 5'-untranslated region (5'-UTR)...