Searchable abstracts of presentations at key conferences in endocrinology

ea0081p736 | Thyroid | ECE2022

Thyroid hormones and platelet activation in COVID-19 patients

Colonnello Elena , Curreli Mariaignazia , Tozzi Rossella , Criniti Anna , Lorusso Emiliano , Gnessi Lucio , Gandini Orietta , Lubrano Carla

Background: The relationships between thyroid hormones (TH) and platelets (PLT) have not been fully established. Physiological concentrations of L-thyroxine (T4) activate human PLT resulting in ATP release and aggregation. On the other hand, subclinical hypothyroidism has been frequently associated with hypercoagulability, in particular mean platelet volume (MPV), a marker of platelet activation, has been found higher in patients with subclinical hypothyroidism. A possible pro...

ea0090p626 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Comparison of the Effects of a Ketogenic Diet and an Isocaloric Balanced Diet administered to Obese patients on Quality of Life and Sleep: a Randomized Clinical Trial

Gangitano Elena , Elena Spoltore Maria , Lenzi Andrea , Gnessi Lucio , Ray David

Introduction: The prevalence of obesity and metabolic disturbances is worryingly increasing worldwide, therefore the study of their pathophysiology is extremely important to find new strategies for their treatment. Obesity has an impact not only on the metabolism of the patients, but also profoundly influence their daily life, and potentially affect the quality of life and the quality of sleep. These latter are strictly related to the circadian rhythm of the individuals that, ...

ea0049gp168 | Obesity | ECE2017

Effects of short sleep duration on energy metabolism and energy balance in subjects with overweight and obesity

Poggiogalle Eleonora , Donini Lorenzo , Gnessi Lucio , Mariani Stefania , Calabretto Marianna , Luisi Federica , Lenzi Andrea , Lubrano Carla

Introduction: The chronic reduction of sleep duration is associated to an increased risk of weight gain, but mechanistic aspects remain to be fully elucidated. The aim of our study was to examine the relationship between short sleep duration and energy metabolism, fuel selection and energy balance in overweight and obesity. Methods: Inclusion criteria were: age 18–65 years, BMI ≥25 kg/m2. Use of any CNS medications, any psychiatric disorders and night shi...

ea0081p342 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

IGF1-zSDS in patients suffering from obesity with or without metabolic syndrome: a cross-sectional study in 2032 subject

Masi Davide , Risi Renata , Tozzi Rossella , Gangitano Elena , Curreli Mariaignazia , Watanabe Mikiko , Mariani Stefania , Gnessi Lucio , Lubrano Carla

Background: Metabolic syndrome (MS) is associated with increased mortality, and the key factors predictive of its development among patients with obesity are still unclear. We recently demonstrated with a machine learning approach that Insulin-like Growth Factor 1 (IGF-1) is a novel marker of metabolic health and that in individuals with obesity, lower IGF-1 levels are associated with increased metabolic deterioration. However, the interpretation of IGF-1 serum measurement is ...

ea0090p612 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Obesity-Associated Hepatic Steatosis, Somatotropic Axis Impairment and Ferritin Levels are Strong Predictors of COVID–19 Severity

Masi Davide , Gangitano Elena , Marino Luca , Criniti Anna , Ballesio Laura , Anzuini Antonella , Angeloni Antonio , Gnessi Lucio , Gandini Orietta , Lubrano Carla

Purpose: From a clinical perspective, the full spectrum of Sars–CoV–2–infected patients has not yet been defined. This study aimed to evaluate whether liver density on computed tomography (CT) scan and serum insulin-like growth factor 1 (IGF1) values can explain the clinical variability of COVID–19 cases.Methods: We performed a retrospective study including SARS–CoV–2–infected patients hospitalized from March 2020 to Ma...

ea0081p103 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The crosstalk between adiposity and bone: a potential role for SIRT1 and sclerostin

Tozzi Rossella , Masi Davide , Cipriani Fiammetta , Elena Spoltore Maria , Contini Savina , Watanabe Mikiko , Basciani Sabrina , Lubrano Carla , Gnessi Lucio , Mariani Stefania

Background and aim: Sirtuin1 (SIRT1) and sclerostin play important roles in adipose tissue and bone metabolism. SIRT1 pharmacological induction improves bone quality both in murine and human models and- as adiposity increases – its expression decreases both in peripheral tissues and blood. Sclerostin reduces osteoblasts’ differentiation and mineralization and is associated with DMT2, obesity and cardiovascular risk. We evaluated the circulating SIRT1 and sclerostin r...

ea0081p142 | Pituitary and Neuroendocrinology | ECE2022

Chondrosarcoma of the cavernous sinus treated with postoperative proton radiation therapy: case report and endocrinological follow up after 36 months

Masi Davide , risi renata , balena angela , caputi alessandra , elena spoltore maria , rossetti rebecca , watanabe mikiko , Tozzi Rossella , Gangitano Elena , mariani stefania , Lenzi Andrea , gnessi lucio , lubrano carla

Case Summary: In May 2018, a 22-year-old man was admitted to the Emergency Room of Polyclinic Umberto I Hospital of Rome, because of progressive headaches and binocular diplopia. Brain MRI revealed a heterogeneous T1WI-hypointense and T2WI-hyperintense mass of 40x28x25 mm (CC, LL, AP) including calcification areas in the left paramedian region of the clivus invading the homolateral cavernous sinus. The patient underwent partial tumour resection via infratemporal approach and a...

ea0090ep1108 | Late Breaking | ECE2023

Utility of nutritional ultrasound for body composition in patients affected by obesity and overweight. Utility of nutritional ultrasound for body composition in patients affected by obesity and overweight

Tozzi Rossella , Garcia Delgado Yaiza , Maria Sanchez Hernandez Rosa , Gil Quintana Yaiza , Hernandez Hernandez Diego , Davila Veronica , Boronat Mauro , Mariani Stefania , Gnessi Lucio , Maria Claudia Wagner Anna

Background and aim: Dual energy X-ray absorptiometry (DXA) is considered the gold standard to evaluate BC, even if it requires the use of radiations, an expensive equipment and cannot be performed at the patient’s bedside. Nutritional ultrasound (NU) evaluates BC through the assessment of muscle mass and the abdominal subcutaneous (superficial and deep-layer) and visceral adipose tissue. We aimed at comparing the accuracy and reliability of this emerging tool with DXA in ...

ea0063gp141 | Obesity | ECE2019

Dietary inflammatory index is differently associated with ectopic fat depots in overweight and obese adults

Poggiogalle Eleonora , Lubrano Carla , Luisi Federica , Hebert James R , Shivappa Nitin , Di Martino Michele , Gnessi Lucio , Mariani Stefania , Lenzi Andrea , Donini Lorenzo M.

Introduction: In overweight and obesity energy unbalance is responsible for the accumulation of ectopic fat. Excess energy and metabolic alterations, namely insulin resistance, may favor ectopic fat depositions. However, the role played by dietary factors, especially the pro-inflammatory properties of dietary patterns, in ectopic fat storage is not thoroughly understood. The aim of our study was to investigate the association between the Dietary Inflammatory Index (DII) and di...

ea0049ep702 | Obesity | ECE2017

Obesity, cardiomyopathy and anabolic hormones

Gangitano Elena , Costantini Daniela , Tozzi Rossella , De Giorgi Francesca , Poggiogalle Eleonora , Mariani Stefania , Petrangeli Elisa , Donini Lorenzo Maria , Barbaro G. , Gnessi Lucio , Lubrano Carla

Obesity is associated with hemodynamic alterations that may lead to heart failure (HF), through the development of cardiac structural abnormalities and impairment of ventricular function. Obesity-related neurohormonal and metabolic disturbances may predispose to HF, even in the absence of comorbidities. Excess adipose tissue and in particular visceral adiposity contributes to the altered production of a number of anabolic hormones also involved in the regulation of the cardiac...