Endocrine Abstracts

Cytochrome P450 (CYP) 1A1 plays a major role in the metabolic activation of procarcinogens to carcinogens via aryl hydrocarbon receptor (AhR) pathway. In estrogen responsive cancers, 17β-estradiol (E2) may influence on AhR dependent expression of CYP1 family via the interaction between estrogen receptor (ER) and AhR. In the present study, the effect of E2/ER on the expression of AhR and CYP1A1 genes was investigated for BG-1 ovarian cancer expressing ER. In reverse transc...

Fenhexamid and cyprodinil are antifungal agents used in agricultural applications and present at measurable amounts in fruits and vegetables. In this study, the effects of fenhexamid and cyprodinil on cancer cell viability and metastasis were examined and the expression levels of proteins such as cyclins D1 and E, and cathepsins B and D were analysed in BG-1 ovarian cancer cells with oestrogen receptors (ERs). BG-1 cells were cultured with 0.1% DMSO (control), 17β-oestrad...

Environmental factors such as high meat consumption, caffeine, cigarette smoking, and endocrine disrupting chemical (EDCs) may enhance the risk of ovarian cancer. Cytochrome P450 (CYP) 1A1 may play a major role in metabolic activation of procarcinogens to carcinogens. 2,3,7,8-Tetrachlorodibenzo-ρ-dioxin (TCDD) is a commonplace pollutant and a promoter of carcinogenesis as the most potent substance. In this study, we examined the effects of TCDD in the presence of...

Phthalates are mainly used as substances added to plastics for increase flexibility, durability and transparency. Although phthalates have been reported to act as endocrine-disrupting chemicals (EDCs) and appear to cause detrimental effects on human health, diverse cancers and diseases, exact effect(s) and underlying mechanism(s) remain uncovered. The estrogenic activity of EDCs is partially associated with ability to stimulate cell viability in estrogen-dependent cancers expr...

Fenhexamid (Fen) and cyprodinil (Cyp) are antifungal agents used in agricultural applications. In this study, to examine the effects of two-pesticides on cancer cell viability and metastasis via estrogen receptor pathway, the ER positive-MCF-7 and ER negative-MDA-MB-231 breast cancer cells were used. MCF-7 and MDA-MB-231 were cultured with 0.1% DMSO (control), 17β-estradiol (E2; 1×10−9 M), Fen (10−5–10−7</s...

Background: Human immunodeficiency virus (HIV) infection and the Acquired Immune Deficiency Syndrome (AIDS) are health problems with infected individuals frequently manifesting some abnormalities including significant weight loss. This has been associated withtumor necrosis factor alpha and interleukin 1β production by circulating mononuclear white blood cells in patients with HIV infection andaltered metabolism due to cytokine dysregulation and metabolic demands of antir...

Background: Human immunodeficiency virus (HIV) infection and the Acquired Immune Deficiency Syndrome (AIDS) are health problems with infected individuals frequently manifesting some abnormalities including significant weight loss. This has been associated withtumor necrosis factor alpha and interleukin 1β production by circulating mononuclear white blood cells in patients with HIV infection andaltered metabolism due to cytokine dysregulation and metabolic demands of antir...

Introduction: False memory, that is, remembering events, prohibitions and recommendations that did not happen. This phenomenon has long been known in forensics as it seems to be much more recognized in everyday life. This also applies to patients who could significantly interfere with communication with the doctor and education opportunities. In the face of surprisingly few papers on this subject regarding diabetes, we would like to present our observation.<p class="abstex...

Fenhexamid (Fen) is a fungicide used to treat the gray mold of fruits and vegetables. In this study, the ER positive-MCF-7 breast cancer cells were used to examine the effects of Fen on breast cancer progression. MCF-7 cells were cultured with 0.1% DMSO (control), 17β-estradiol (E2; 1×10−9 M) and Fen (10−5–10−7 M) in the absence or presence of ICI 182,780 (ICI, ER antagonist, 10−8 M) or Pictilis...

Cytochrome P450 (CYP) 1A1 plays a major role in the metabolic activation of procarcinogens to carcinogens via aryl hydrocarbon receptor (AhR) pathway. Especially, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known as an agonist of AhR. In estrogen responsive cancers, 17β-estradiol (E2) may influence on AhR dependent expression of CYP1 family via the interaction between estrogen receptor (ER) and AhR. In the present study, the effect of E2/ER on the expression of AhR and ...