ea0035p2 | Adrenal cortex | ECE2014
Heinze Britta
, Schirbel Andreas
, Michelmann David
, Nannen Lukas
, Ries Martin
, Thomas Elke
, Gobel Heike
, Allolio Bruno
, Hahner Stefanie
Objective: We have developed (123/131I)iodometomidate (IMTO) for specific adrenal imaging and radiotherapy of adrenocortical carcinoma. IMTO binds with high affinity and specificity to the two adrenocortical enzymes aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1). Metabolic analysis has revealed very rapid metabolization of IMTO both in vitro and in vivo by hepatic esterases. Due to the low metabolic stability of (123/131</su...