Searchable abstracts of presentations at key conferences in endocrinology

ea0015p143 | Diabetes, metabolism and cardiovascular | SFEBES2008

Androgens increase blood pressure in orchiectomized male Wistar rats similar to high salt diet

Hofmann Peter , Michaelis Marten , Goetz Franziska , Quinkler Marcus

Introduction: With the onset of puberty blood pressure increases more in men than in women while boys and girls do not show any gender differences in blood pressure. Androgens are known to play an important role in renal tubular epithelial cell growth, hypertrophy and erythropoetin production and may be important determinants of sex-specific differences in blood pressure. However the exact mechanisms are not clear yet.Methods: Male Wistar rats aged 8&#15...

ea0014p535 | (1) | ECE2007

Neurotropic profiles of androgens - mechanisms and targets

Goetz Franziska , Patchev Vladimir K , Rohde Wolfgang , Patchev Alexandre V

Identification of pure neural androgenic effects is difficult due to 1) regional distribution of androgen receptors (AR) in the CNS; 2) cross-talk between molecular pathways of steroid hormone signalling, and 3) chemical nature and biotransformation of androgens in the CNS. Testosterone is transformed in the CNS by 5α-reductase and aromatase to the pure AR-agonist dihydrotestosterone (DHT) and the estrogen receptor-agonist estradiol, respectively. Decreased sexual activit...