Searchable abstracts of presentations at key conferences in endocrinology

ea0025oc4.3 | Bone and diabetes | SFEBES2011

Rapid bone turnover responses to increased hypothalamic–pituitary–thyroid-axis activity are mediated by thyroid hormones

Gogakos Apostolos , Murphy Elaine , Bassett Duncan , Williams Graham

Increased hypothalamic–pituitary–thyroid (HPT) axis activity results in high bone turnover. T3 stimulates osteoblast and osteoclast activities, whereas TSH is proposed to inhibit bone turnover directly. Resolving the relative importance of T3 and TSH is complicated by their physiological inverse relationship. We studied 10 controls and 4 patients with resistance to thyroid hormone (RTH), in which mutation of thyroid hormone receptor beta (THR...

ea0081p18 | Adrenal and Cardiovascular Endocrinology | ECE2022

Covid-19 infection: incidental diagnosis of pheochromocytoma in an adolescent bearing an uncommon mutation

Efstathiadou Zoi , Gogakos Apostolos , Komzia Paraskevi , Goulopoulou Sophia , Linos Dimitrios , Kita Marina

Introduction: Chest computed tomography imaging in patients with Covid-19 infection often reveals incidental adrenal lesions, which are subsequently investigated, after recession of the infection.Purpose: Description of a pheochromocytoma that was accidentally diagnosed in a teenager, during her hospitalization with Covid-19.Case description: A 17-year-old girl, who was diagnosed with covid-19 infection, by molecular testing 6 days...

ea0081ep22 | Adrenal and Cardiovascular Endocrinology | ECE2022

Adrenal ganglioneuroma: presentation of two cases

Michou Athanasia , Efstathiadou Zoi , Komzia Paraskevi , Gogakos Apostolos , Divaris Efstathios , Kourkouta Georgia , Kita Marina

Introduction: Adrenal ganglioneuroma (AGN) is a rare (about 470 described cases), benign tumor arising from the neural crest tissue. These tumors are usually asymptomatic and incidentally detected. They have variable radiological features that often raise suspicion of malignancy. AGN are diagnosed at a mean age of 50 years, have no gender preference and are rarely associated with genetic syndromes.Aim: The presentation of two male patients, 24 and 53 yea...

ea0081ep114 | Adrenal and Cardiovascular Endocrinology | ECE2022

Late diagnosis of adrenoleukodystrophy in an adult patient with tetraparesis and addisonian crisis.

Gogakos Apostolos , Aggelaki Aliki , Dougalis Apostolos , Kourkouta Georgia , Kita Marina , Efstathiadou Zoi

Introduction: Adrenoleukodystrophy (ALD) is a rare, X-linked inherited, genetic disease, characterized by a disorder of peroxisome metabolism, leading to the accumulation of very long-chain fatty acids (VLCFAs) mainly at the central nervous system and the adrenal glands. It usually occurs in childhood, but there are types of the disease that manifest later in life.Case: A 57-year-old man with a history of progressive spastic paresis, starting at the age ...

ea0081ep676 | Pituitary and Neuroendocrinology | ECE2022

Idiopathic isolated adrenocorticotropic hormone deficiency

Komzia Paraskevi , Gogakos Apostolos , Kalograni Fanny , Tsoutsas Georgios , Kita Marina , Efstathiadou Zoi

Introduction: Idiopathic Isolated Adrenocorticotropic hormone (ACTH) deficiency (IIAD) is a rare cause of secondary adrenal insufficiency. It can present with a variety of clinical symptoms, mainly chronic fatigue and euvolemic hyponatraemia, and may coexist with autoimmune disease, most commonly Hashimoto’s thyroiditis. Radiographically, an empty sella turcica image can be seen. We present 3 cases of isolated ACTH deficiency.Case 1: A 47-year-old w...

ea0081ep1149 | Thyroid | ECE2022

A female patient with diffuse sclerosing variant of papillary thyroid cancer and background autoimmune thyroiditis

Efstathiadou Zoi , Michou Athanasia , Divaris Efstathios , Gogakos Apostolos , Panagiotou Athanasios , Hytiroglou Prodromos , Kita Marina

Introduction: Diffuse sclerosing variant of papillary thyroid carcinoma (DSPC) represents a rare but rather more aggressive subtype of PTC.Purpose: Description of a patient with DSPC and background autoimmune thyroiditis.Case description: A 33-year-old female patient reported extensive neck swelling that had progressed over several months. The patient had been diagnosed with hypothyroidism attributed to autoimmune thyroiditis, 3 ye...

ea0063p718 | Pituitary and Neuroendocrinology 2 | ECE2019

A rare case of a TSH/GH secreting pituitary macroadenoma

Gogakos Apostolos , Efstathiadou Zoe , Tsirou Efrosini , Lypiridou Sofia , Mintziori Gesthimani , Kostopoulos Ioannis , Foroglou Nikolaos , Kita Marina

Introduction: Thyrotropin (TSH) secreting pituitary adenomas (TSHomas) are very rare and account for less than 2% of all pituitary adenomas. They present with elevated levels of fT4 and normal to high levels of TSH. About 25% of TSHomas co-secrete other anterior pituitary hormones. Growth hormone (GH) is the most commonly co-secreted hormone, followed by prolactin (PRL) and gonadotropins. Herein, we report a case of pituitary adenoma with simultaneous secretion of TSH and GH.<...

ea0063p1073 | Pituitary and Neuroendocrinology 3 | ECE2019

Diagnostic challenges in Ectopic Cushing’s Syndome: report of 2 cases

Komzia Paraskevi , Efstathiadou Zoe , Karaiskos Theodoros , Tirkalas Sotiris , Gogakos Apostolos , Kita Marina

Introduction: Ectopic Cushing’s Syndrome (ECS) accounts for 5-10% of all cases of endogenous hypercortisolism. ACTH secreting intrathoracic masses is the most common cause of ECS. We present two patients with ectopic Cushing’s syndrome, with particularities in diagnosis.Case 1:: A 59-year-old female presented with arterial hypertension, and osteoporosis, along with weight gain and facial plethora, starting two years before. Screening tests were...

ea0028oc1.3 | Young Endocrinologists prize session | SFEBES2012

Effect of selenium status on the skeleton in post-menopausal women: the OPUS study

Gogakos Apostolos , Hoeg Antonia , Murphy Elaine , Mueller Sandra , Reid David , Gluer Claus , Felsenberg Dieter , Roux Christian , Eastell Richard , Koehrle Josef , Schomburg Lutz , Williams Graham

T3-action is regulated by three iodothyronine deiodinases, which contain selenium in the active site. It is proposed that Se availability regulates thyroid function. OPUS is a European population-based prospective cohort study of post-menopausal women in which we showed thyroid function within the upper normal range is associated with reduced bone mineral density (BMD) and increased non-vertebral fracture risk. Using strict exclusion criteria we defined reference ranges for th...

ea0021oc4.4 | Bone and parathyroid | SFEBES2009

Rapid screening for novel bone phenotypes in 100 consecutive lines from the Wellcome Trust Sanger Institute Gene Targeting Programme

Gogakos Apostolos , Bassett Duncan , van der Spek Anne , Evans Holly , White Jacqui , Ramirez-Solis Ramiro , Steel Karen , Bradley Allan , Thakker Rajesh , Croucher Peter , Williams Graham

The Wellcome Trust Sanger Institute Gene Targeting Programme is deleting all mouse genes and has already generated 400 knockout mice in a C57/BL6N background with a further 4000 genes targeted in ES cells. Two hundred and fifty new knockouts will undergo limited phenotyping each year. However, the programme lacks a sensitive and sufficiently detailed screen for individual physiological systems, each of which requires high throughput methodology and unique expertise. Thus, we p...