Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp254 | Thyroid non cancer | ECE2018

Proteome analysis of 3,5-T2-treated primary mouse hepatocytes

Golchert Janine , Lietzow Julika , Volker Uwe , Homuth Georg , Kohrle Josef

Introduction: Besides the classical thyroid hormones T4 and T3 the endogenous thyroid hormone metabolite 3,5-diiodothyronine (3,5-T2) attracted attention during the last years due to its metabolic activity. 3,5-T2 exerts thyromimetic action on the hypothalamus-pituitary-thyroid axis and the heart as well as on energy and lipid metabolism. In previous liver transcriptome analyses of 3,5-T2-treated lean and diet-induced obese male mice, effects on hepatic lipid, steroid, xenobio...

ea0049oc3.4 | Receptors & Signalling | ECE2017

Treatment with thyroid hormone metabolite 3,5-T2 alters cholesterol and sex steroid metabolism in mouse liver

Lietzow Julika , Golchert Janine , Homuth Georg , Jonas Wenke , Ohlsson Claes , Landin Andreas , Poutanen Matti , Kohrle Josef

Recent findings revealed 3,5-diiodo-L-thyronine (3,5-T2) as a metabolically active iodothyronine affecting hepatic energy and lipid metabolism. Therefore, 3,5-T2 has been proposed as a potential hypolipidemic agent for treatment of obesity and its hepatic aftermath. So far only limited data exists relating to the effects of 3,5-T2 on metabolism in euthyroid mammals maintained on high-fat diet from the day of weaning onwards. Therefore, we performed a study in wh...

ea0041oc4.2 | Thyroid - Clinical | ECE2016

Molecular fingerprint of experimental thyrotoxicosis on human metabolism: combined metabolome and proteome study

Pietzner Maik , Engelmann Beatrice , Kacprowski Tim , Golchert Janine , Dirk Anna-Luise , Homuth Georg , Hammer Elke , Nauck Matthias , Wallaschofski Henri , Munte Thomas , Friedrich Nele , Volker Uwe , Brabant Georg

The functional state of the thyroid is usually determined by thyrotropin (TSH), whose serum levels depend on circulating thyroid hormone (TH) levels. This feedback mechanism is tightly controlled in the individual and contrasts broad reference range for TSH in the general population, leading to the concept of subclinical thyroid disease. We studied a model of experimental thyrotoxicosis in humans employing an untargeted metabolome and proteome approach. This allowed us to gain...

ea0073pep15.2 | Presented ePosters 15: Late Breaking | ECE2021

Monocarboxylate transporter 8 deficiency leads to autophagy-induced persistent cathepsin-mediated thyroglobulin processing triggered by insufficient L-type amino acid transporter 2 functionality

Venugopalan Vaishnavi , Al-Hashimi Alaa , Weber Jonas , Rehders Maren , Golchert Janine , Homuth Georg , Verrey Francois , Kirstein Janine , Heuer Heike , Schweizer Ulrich , Wirth Eva , Brix Klaudia

The thyroid gland functions in supplying thyroid hormones (TH) to the body periphery, which is enabled by cathepsin-mediated thyroglobulin proteolysis and TH translocation across membranes by the Mct8, Mct10, and Lat2 transporters. Previously, we showed that cathepsin K-deficient mice feature normal thyroid phenotypes which is, in part, due to the functional compensation through cathepsin L upregulation that is independent of the classical hypothalamus–pituitary–thyr...