Searchable abstracts of presentations at key conferences in endocrinology

ea0003p154 | Genetics | BES2002

The angiotensin II response to an acute exercise stimulus and the angiotensin converting enzyme (ACE) genotype

Woods D , Jones A , Sanders J , Hurel S , Jamshidi Y , Hawe E , Goldstone J , Gohlke P , Humphries S , Montgomery H

The ACE I/D polymorphism is associated with resting ACE activity such that DD>ID>II. The D allele is strongly associated with increased exercise-induced left ventricular hypertrophy (LVH) and cardiovascular risk.Objective: Examine the relation between ACE genotype, exercise, circulating ACE and angiotensin II.Ethical approval was obtained and 17 (9DD, 8II) healthy, male (22.9+/-1.9 years, 178.6+/-2.8cm, 71.9+/-2.2kg) Caucasi...

ea0002p45 | Genetics | SFE2001

Exercise-induced, ACE genotype-dependent rise in serum Angiotensin I-Converting Enzyme

Woods D , Saunders J , Jones A , Hurel S , Jamshidi Y , Hawe E , Goldstone J , Gohlke P , Humphries S , Montgomery H

Background: The ACE I/D polymorphism of the ACE gene, associated with cardiovascular risk and athletic performance, accounts for half the variation in resting ACE. DD subjects have the greatest, ID intermediate, and II subjects the lowest serum ACE. Exercise stimulates the renin-angiotensin system, producing a rise in angiotensin II. 3 small (n=6-8) lab studies suggest serum ACE does not change with exercise, despite a rise in angiotensin II, whereas 2 other studies have demon...