Searchable abstracts of presentations at key conferences in endocrinology

ea0056ep70 | Diabetes, Obesity and Metabolism | ECE2018

Controversies of endocrine treatment in Prader-Willi syndrome: a case report of two monozygotic twins

Gomes Vania , Ferreira Florbela , Bugalho Maria Joao

Introduction: Prader-Willi syndrome (PWS) is a neurobehavioral imprinting disorder, which arises due to an absence of paternally expressed genes within the 15q11.2-q13 region. It is the most common syndromic form of obesity, with an estimated prevalence of about 1 in 25,000 individuals.Case report: we report the case of two monozygotic twins, 20-year-old, naturally conceived, both affected by PWS. They were born by eutocic delivery at 34 weeks of gestati...

ea0063p1192 | Thyroid 3 | ECE2019

Amiodarone-induced thyrotoxicosis: which type?

Gomes Vania , Castro Raquel Vaz de , Ferreira Florbela

Introduction: Amiodarone is a widely used antiarrhythmic drug for refractory atrial or ventricular tachyarrhythmias. Amiodarone-induced thyrotoxicosis (AIT) occurs in up to 6% of patients taking this medication in iodine-sufficient areas of the world and in up to 10% in iodine deficient areas. AIT can be divided into two types: type 1 is a form of iodine-induced hyperthyroidism whereas type 2 is a drug-induced destructive thyroiditis. Type 1 AIT tends to occur in patients with...

ea0041ep656 | Endocrine tumours and neoplasia | ECE2016

Insulinoma misdiagnosed as neurologic disease

Salavessa Judite , Gomes Vania , Alcantara Cristina , Ferreira Florbela

Introduction: Insulinoma is a rare pancreatic endocrine tumor derived from ß cells that secret insulin, which results in hypoglycemia. Most are benign and solitary. The median age at diagnosis is about 47 years. The age range for peak incidence is between 30 and 60 years and it is more prevalent in women. Diagnosis relies on clinical features along with laboratory tests and imaging. However, the nonspecific symptoms and small size of these tumors can lead to difficulties ...

ea0056p252 | Calcium & Vitamin D metabolism | ECE2018

Characterization of the parathyroid hormone requests and hyperparathyroidism etiologies in a tertiary hospital

Gomes Vania , Matias Sampaio , Ferreira Florbela , Proenca Helena

Introduction: Hyperparathyroidism is a disease characterized by excessive secretion of parathyroid hormone (PTH). There are three main etiologies: primary (PHPT), secondary (SHPT) and tertiary hyperparathyroidism (THPT). PHPT is characterized by abnormal regulation of PTH secretion by calcium, resulting in hypersecretion of PTH relative to the serum calcium concentration. SHPT is the overproduction of PTH in context of hypocalcemia, most frequently because of vitamin D deficie...

ea0049ep329 | Clinical case reports - Thyroid/Others | ECE2017

Autosomal dominant hypocalcemia in a Portuguese family: novel mutation in the calcium-sensing receptor gene

Gomes Vania , Ferreira Florbela , Silvestre Catarina , Castro Raquel , Joao Bugalho Maria

Introduction: Autosomal dominant hypocalcemia (ADH) is a rare condition, caused by activating mutations in the calcium-sensing receptor (CASR) gene. Affected individuals have hypocalcemia with inappropriately low parathyroid hormone (PTH) levels.Case report: A 50-year-old woman, asymptomatic, was referred to our Endocrinology department for investigation of hypocalcemia detected in routine blood analysis (serum corrected calcium was 7.4 mg/dl &#...

ea0049ep1055 | Pituitary - Clinical | ECE2017

Hypogonadotropic hypogonadism in a patient with long-term primary hypothyroidism

Vaz de Castro Raquel , Maria Aragues Jose , Ferreira Florbela , Gomes Vania , Wessling Ana , Joao Bugalho Maria

Abstract: We report the case of a 65-year-old man who presented with erectile dysfunction to an appointment in our Endocrinology department. He referred fatigue, weight gain and constipation as secondary complaints that had been steadily evolving throughout the past 4 years. He denied other symptoms such as visual impairment or headaches as well as the consumption of any medications or drugs. His past medical history was unremarkable. On examination, BMI was 25.8 kg/m2</s...

ea0063p1208 | Thyroid 3 | ECE2019

Thyroid uptake in PET-CT: IPO-porto consecutive case series

Ferreira Paulo Carvalho , Sampaio Ines Lucena , Violante Liliana Sobral , Teixeira Joao Pedro , Neves Joao Sergio , Gomes Vania Rodrigues , Mota Filipe , Duarte Hugo

Introduction: Positive radiotracer uptake by the thyroid gland can occur in PET-CT. It’s meaning has led to conflicting results mainly resulting from small studies.Objective: We aim to present a large single institution consecutive case series.Material and methods: Observational, descriptive and retrospective study of the PET-CT scans performed between the years 2000–2017. We searched the word thyroid in the computer imag...

ea0049ep791 | Endocrine tumours and neoplasia | ECE2017

Polyglandular autoimmune syndrome type III b

Vaz de Castro Raquel , Maria Aragues Jose , Ferreira Florbela , Gomes Vania , Wessling Ana , Tavares Lurdes , Ribeiro Joana , Alves Irina , Camilo Fernandes Afonso , Joao Bugalho Maria

: We report the case of a 57-year-old female diagnosed with Grave’s disease fifteen years before (TSH <0.001 U/ml; FT4 2.3 ng/dl; FT3 7.2 ng/dl, TSAbs 17 U/l). Persistency of hyperthyroidism despite antithyroid therapy led to total thyroidectomy three years after the diagnosis. Thereafter, thyroid function remained normal under hormonal replacement with levothyroxine. The patient had also been diagnosed with Pernicious Anemia at 47 years of age after investigation for...

ea0049ep1204 | Clinical case reports - Thyroid/Others | ECE2017

Isolated ocular Miasthenia Gravis and Graves’ disease – a challenging ophtalmopathy

de Castro Raquel Vaz , Aragues Jose Maria , Ferreira Florbela , Gomes Vania , Wessling Ana , Fonseca Ana Claudia , Conceicao Isabel , Bugalho Maria Joao

We report the case of a Caucasian woman presenting with a challenging differential diagnosis of ophtalmopathy. The patient was diagnosed with Graves’ disease during postpartum at the age of 28 (TSH<0.001 U/ml; FT3 6.7 ng/dl; FT4 2.2 ng/dl; TSAb 15 U/l). Besides 16 pack-year smoking history, no other previous disease was known. At examination, exophthalmos grade I/III with bilateral lid retraction was evident. Persistency of the disease despite optimal use of medical a...

ea0049ep1269 | Thyroid (non-cancer) | ECE2017

Effectiveness of radioiodine treatment for autonomous toxic node

Osorio Ana Sofia , Martins Ana Filipa , Gomes Vania , de Castro Raquel Vaz , Nobre Ema , Ferreira Mickael Antoine , Cantinho Guilhermina , Bugalho Maria Joao

Objective: The aim of this study was to evaluate the treatment outcomes in patients with autonomous toxic nodule (ATN) that received a radioiodine treatment (RAIT) and to determine the influence of age, gender, nodule size and iodine activity.Methods: We performed a retrospective study of all RAIT done for hyperthyroidism (n=149) in our hospital during 2014 and 2015. Patients with ATN submitted to RAIT were selected to analysis. We studied 58 pa...