Searchable abstracts of presentations at key conferences in endocrinology

ea0014p281 | (1) | ECE2007

The androgen receptor in the rat choroid plexus

Alves CH , Socorro S , Gonçalves IMT , Santos CRA

The choroid plexus (CP) produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier, being involved in the maintenance of the extracellular milieu of the brain and secretion of several neuroprotective factors. There are several experimental evidences showing that androgens enhance cognition and act as potential protective factors against Alzheimer’s Disease. It has been shown that testosterone exerts neuroprotective actions against oxidative stress, apoptosis, and ...

ea0032p403 | Diabetes | ECE2013

Cardiovascular risk management in the patients with type 2 diabetes mellitus

Kim Doo-Man , Kim Sin Gon , Cho Donghyouk , Kim Chong Hwa , Kim Chul-Sik , Lee Won-Young , Won Kyu Chang

Current guidelines on cardiovascular (CV) disease prevention recommend targeted management after assessment of CV risks using many of available method even if the patient is asymptomatic. This study was performed to explore how CV high-risk is differently detected between two distinct methods: non-invasive test (NIT) and risk calculation and how the awareness of CV high-risk impacts physician and patient behavior for risk management in diabetes patient.A...

ea0022p612 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

The predictors of the response to somatostatin analogue therapy in patients with acromegaly

Kim Dong-Sun , Kim Joo-Hyung , Kim Kim Sin-Gon , Baik Sei-Hyun , Yoo Soon-Jib , Sung Yeon-Ah

Somatostatin analogues (SSA) are widely used for the treatment of patients with acromegaly, and the responses are variable. We investigated the possible predictive factors of the response to SSA therapy in Korean acromegalic patients. Twenty-eight patients were retrospectively analysed, who were treated by surgery and adjunctively SSA. Somatostatin suppression tests (SST, hourly GH measurements for 3 h following 100 μg somatostatin injection) were done before SSAs were gi...

ea0049gp91 | Diabetes &amp; complications 2 | ECE2017

Dipeptidyl peptidase-4 inhibitor therapy and risk of diabetic retinopathy: a population based study

Kim Nam Hoon , Kim Hye Suk , Yoo Hye Jin , Seo Ji A , Kim Nan Hee , Choi Kyung Mook , Baik Sei Hyun , Lee Juneyoung , Noh Jung Hyun , Kim Sin Gon

Background: Given the possible association between dipeptidyl peptidase-4 (DPP-4) inhibitor and risk of diabetic retinopathy (DR), we examined whether DPP-4 inhibitors are beneficial or harmful for DR compared with other glucose-lowering agents.Methods: From a Korean population-based cohort, we identified 67,743 adults with type 2 diabetes treated with oral glucose-lowering agents between 2008 and 2013. Matching (1:1) was done for comparative groups: eve...

ea0049ep1451 | Thyroid (non-cancer) | ECE2017

Comparative analysis of clinicopathological characteristics between Korean and Italian thyroid cancer patients

An Jee Hyun , Kim Sin Gon , Kim Hoon Yub , Jung Kwang Yoon , Chae Yang Seok , Dionigi Gianlorenzo , Rausei Stefano , Tanda Maria Laura , Piantanida Eliana , Rosa Stefano La

Background: The incidence of thyroid cancer in South Korea has increased rapidly. Increase in medical surveillance and access to health care services have enhanced the detection of asymptomatic tumors. We investigated the differences of tumor characteristics between South Korean patients and Northern Italian patients subject to different healthcare systems.Methods: The demographic, histopathologic and management features of thyroid cancer operated in two...

ea0014p276 | (1) | ECE2007

Transthyretin is up-regulated by androgens in mice liver and choroid plexus

Santos Cecilia RA , Henrique Alves C , Saraiva Maria Joao , Abreu Raquel , Baltazar Graça , Socorro Silvia , Quintela Telma P , Gonçalves Isabel MT

Transthyretin (TTR) is well documented as a carrier for thyroid hormones. It also binds retinol binding protein preventing its filtration trough the kidneys and therefore is involved in delivering retinol to target cells. Moreover, TTR sequesters amyloid-beta impairing its deposition in nervous tissues and possibly contributing to its removal. Despite its importance in mammalian physiology, there are few studies regarding the regulation of TTR synthesis. In silico analy...

ea0037gp.16.03 | Diabetes and obesity–Clinical obesity and cardiovascular | ECE2015

The dipeptidyl peptidase-IV inhibitor (gemigliptin) inhibits the expression of vascular adhesion molecules and inflammatory cytokines in HUVECs via Akt- and AMPK-dependent mechanisms

Hong Ho Cheol , Hwang Hwan-Jin , Lee Hyun Jung , Lee Min Jung , Seo Ji A , Kim Sin Gon , Kim Nan Hee , Choi Kyung Mook , Choi Dong Seop , Baik Sei Hyun , Yoo Hye Jin

Recently, dipeptidyl peptidase-IV (DPP-IV) inhibitor, a major anti-hyperglycaemic agent, has received substantial attention as a possible therapeutic target for inflammatory diseases such as atherosclerosis. However, the direct molecular mechanisms through which DPP-IV inhibitor mediates anti-inflammatory effects in vascular endothelial cells have not been clarified. The effects of the DPP-IV inhibitor, gemigliptin, were analysed in human umbilical vein endothelial cells (HUVE...

ea0073aep311 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Impact of the COVID pandemic and lockdown in the glycemic and weight control of patients with type 1 and type 2 diabetes – data from a Portuguese hospital

Franco Sara , Bastos Filipa C. , Ana Gonçalves Ferreira , Barbosa David , Ricardo Capitão , Costa Maria Manuel , Luiz Henrique Vara , Manita Isabel , Cordeiro Maria Carlos , Luísa Raimundo , Portugal Jorge

IntroductionDue to the COVID pandemic, Portugal was forced to start lockdown on March 18 th that lasted until June 1st. Lockdown caused a lot of changes in the daily activities of the Portuguese people, such as eating habits, exercise, time spent at home and stress management. After the lockdown people noticed difficult access to healthcare.ObjectiveOur aim was to evaluate if these changes had an i...

ea0073ep210 | Thyroid | ECE2021

Epithelioid hemangioendothelioma with thyroid involvement – case report

Franco Sara , Cardoso Catarina , Correia Rafaela , Sequeira Mafalda , Dinis Sousa Magno , Filipa C. Bastos , Sequeira Pedro , Raquel Miranda Ana , Abecassis Francisca , Ana Gonçalves Ferreira , Barbosa David , Vara Luiz Henrique , Jorge da Cunha Oliveira

Epithelioid hemangioendotheliomas (EHE) are rare vascular tumors that are typically low to intermediate grade, but they can also have an aggressive behaviour. Mortality rate is dependent on the tumor location. It is frequently a solitary lesion located in the superficial or deep soft tissues, but they can be found in liver, lungs (normally multifocal), pleura, bones, lymph nodes and rarely in the thyroid gland. We describe a case of metastatic EHE with involvement of the thyro...

ea0070aep29 | Adrenal and Cardiovascular Endocrinology | ECE2020

Treatment outcomes in 198 patients of the portuguese adrenocortical carcinoma register

Nunes da Silva Tiago , Catarino Diana , Paiva Isabel , Chaves Carolina , Costa Claudia , Castro Raquel , Paula Marques Ana , Souteiro Pedro , Pereira Maria , Machado Catarina , Belo Carlos , Simões Helder , Cortes Luisa , Pereira Bernardo , Anselmo João , Sapinho Inês , Gonçalves Ferreira Ana , Teresa Pereira Maria , Fonseca Liliana , Fernandes Isabel , Rita Elvas Ana , Donato Sara , Martins Anabela , Fajar Laura , Martinho Mariana , Garrido Susana , Ferreira Marta

Introduction: Adrenocortical carcinoma (ACC) is a rare entity, usually associated with a poor prognosis. There are still many areas of uncertainty regarding its approach.Methods: A Portuguese ACC register was established in 2020, including information from 24 endocrine centres. Kaplan-Meier was used to calculate overall survival and recurrence; log- rank test to assess survival and progression free survival (PFS) differences between groups; cox-regressio...