Searchable abstracts of presentations at key conferences in endocrinology

ea0014p11 | (1) | ECE2007

Blocking undesired leptin action in vivo with leptin antagonists prepared by site-directed mutagenesis of human, ovine, rat and mouse leptin site III

Niv-Spector Leonora , Gonen - Berger Dana , Salomon Gili , Callebaut Isabelle , Djiane Jean , Gertler Arieh

Recent reports have revealed that leptin’s effects are not restricted to central control of body weight, demonstrating instead that leptin is a pleiotropic hormone with a wide variety of different biological actions. Leptin exhibits undesirable effects in autoimmune diseases, in atherosclerosis, and possibly in several types of cancer, and increases the risk of cardiovascular disease in obese people. Therefore, preparation of reagents capable of abolishing leptin’s a...