Searchable abstracts of presentations at key conferences in endocrinology

ea0026p212 | Pituitary | ECE2011

Efficacy and safety of the use of the recombinant GH receptor antagonist pegvisomant (PGV) in acromegaly. Evaluation of its use in 13 patients treated in a pituitary disorders unit

Dominguez-Lopez M , Gonzalez-Molero I , Garcia-Arnes J

Introduction: The recombinant GH receptor antagonist pegvisomant (PGV) is actually used for the treatment of acromegaly when surgery and medical therapy with somatostatin analogues (SSA) have failed. Long term safety and effectiveness need to be evaluated.Material and methods: Retrospective analysis of clinical data from all patients treated with pegvisomant in a pituitary disorders unit.Results: Thirteen patients are being treated...

ea0037ep459 | Diabetes (complications & therapy) | ECE2015

Risk factors, aetiology, and prognosis in patients with ischaemic stroke and diabetes mellitus

Silva-Fernandez Julia , Garcia-Ruiz Rafael , Moreno-Moreno Paloma , Garcia-Ruiz Rosa M , Gonzalez-Pereira Carolina

Objective: To describe the clinical, aetiological and prognostic differences in diabetic and non-diabetic ischaemic stroke (IS) patients.Materials and methods: Retrospective analysis of prospective series of IS patients. Patients were classified as non-DM and DM patients. Demographic and clinical characteristics were compared between two groups. IS prognosis was evaluated by modified Rankin scale (mRS) and NIHSS (NIH stroke scale)....

ea0032p312 | Clinical case reports - Thyroid / Others | ECE2013

Report of a case of hyperandrogenism in a postmenopausal woman

Dominguez-Lopez M , Gonzalez-Molero I , Soriguer F , Gonzalo-Marin M , Ruiz de Adana MS

Objective: To report a case of hyperandrogenism attributable to the presence of an ovarian Leydig cell tumor secreting testosterone in a postmenopausal woman.Methods: The laboratory, radiologic, and pathologic findings in our case are described.Results: A 59-year-old woman presented with a history of gradual increase in facial and body hair, scalp hair loss, male pattern baldness, and deepening of her voice, beginning 5–6 year...

ea0029p404 | Clinical case reports - Thyroid/Others | ICEECE2012

Gastrostomy solves severe hypoglycemias after bariatric surgery

Gonzalo Marin M. , Gonzalez-Molero I. , Dominguez-Lopez M. , Garcia Arnes J.

Introduction: Patients with bariatric surgery require close monitoring because of possible metabolic complications. It has been published some cases of severe and persistent hypoglycemias resistant to diet and pharmacologic treatment being necessary a pancreatectomy. We present a case report of nesidioblastosis after gastric bypass that required subtotal pancreatectomy but despite this, hypoglycemias persisted. Before performing total pancreatectomy we placed a tube feeding in...

ea0026p664 | Diabetes therapy | ECE2011

Clinical effectiveness of a bolus calculator in patients with type 1 diabetes mellitus treated with insulin pump

Dominguez-Lopez M , Gonzalez-Molero I , RuizdeAdana M , Guerrero M , Cardona I , Colomo N , Soriguer F

Objective: Calculation of accurate insulin boluses is one of the major problems related to intensive insulin regimens. A bolus calculator (BC) incorporated into the insulin pump estimates the dose of insulin to be administered at the meal and makes calculation easier and more precise.The aim of the present study was to assess the efficacy of a BC on glycaemic control of patients with DM1 on CSII.Material and methods: We enrolled 20...

ea0007s31 | Joint BES and EFES symposium: Neuroactive steroids: implications for disease and healthy ageing | BES2004

Effects of neuroactive steroids on myelination

Melcangi R , Ballabio M , Gonzalez L , Gyenes C , Leonelli E , Magnaghi V

It is now well known that peripheral nervous system (PNS) is able to synthesize neurosteroids and to convert them, or hormonal steroids coming from the periphery, in neuroactive steroids. Moreover, PNS possess both classical (e.g., progesterone receptor, PR, androgen receptor, AR) and non-classical (e.g., GABAA receptor) steroid receptors and consequently may represent a target for the action of neuroactive steroids. Our data have indicated that neuroactive steroids, like for ...

ea0006oc6 | Young Endocrinologist Session | SFE2003

Crosstalk between IGF signalling and cadherin-mediated cell adhesion promotes myogenic differentiation

Lovett F , Gonzalez M , Carter E , Cobb L , Salih D , Tripathi G , Holding C , Pell J

The IGF-I receptor (IGF-IR) growth/survival pathways are engaged in crosstalk with pathways induced by cell-cell interactions. Different elements of the IGF-IR signalling system also affect the phosphorylation status of molecules involved in the regulation of cadherin-mediated cell-cell adhesion, such as catenins. In addition, the IGF-IR has been shown to co-precipitate with cell adhesion complexes.In this study, the crosstalk between IGF signalling and ...

ea0003p99 | Diabetes & Metabolism | BES2002

Expression of purinergic receptors in human insulin-secreting cells in health and disease

#A-M|#Gonzalez|# , Shepherd R , Lee A , Hussain K , Clayton P , Aynsley-Green A , Lindley K , Dunne M

ATP-evoked signalling events are known to promote release of insulin from pancreatic beta-cells in a Ca2+-dependent manner. In rodent beta-cells and insulin-secreting cell lines, this is mediated by purinergic receptors and there is evidence for the involvement of both P2X and P2Y subtypes. Here,we have used human insulin-secreting cells to examine the expression of purinoceptors in control and disease tissue. Intact islets and isolated beta-cells were obtained from...

ea0041ep510 | Diabetes complications | ECE2016

Stroke recurrence (but not mortality) is higher among diabetic and prediabetic patients

Silva-Fernandez Julia , Garcia-Ruiz Rafael , Garcia-Ruiz Rosa M , Carmen Blanco-Valero M , Gonzalez-Pereira Carolina

Introduction: Diabetes Mellitus (DM) and prediabetic states (pre-DM) are well known risk factors for stroke. Admission blood glucose level and its control during hospital stay, help predicting arterial recanalization after thrombolysis and middle and long term prognosis. We analysed recurrence, mortality and nosocomial infectious complications in DM, pre-DM and patients without previous or newly diagnosed DM or pre-DM.Methods: Descriptive analysis in con...

ea0026p663 | Diabetes therapy | ECE2011

Evaluation of adolescents type 1 diabetic patients after transition from paediatric to adult care

Dominguez-Lopez M , Gonzalez-Molero I , RuizdeAdana-Navas S , delPino A , Lopez J P , Fernandez J D , Olveira G , Soriguer F

Objective: Our objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of the patients. The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents and reveal from the perspective of the adolescents living with type 1 diabetes their experiences surrou...