Searchable abstracts of presentations at key conferences in endocrinology

ea0031p6 | Bone | SFEBES2013

Retinoic acid and IGF1 stimulate the differentiation of human primary osteoblasts to osteocytes in 3D collagen gels

Goring Sarah , Scully Nicole , Mason Deborah , Evans Bronwen

Osteocytes differentiate from osteoblasts, are embedded in mineralised matrix and are critical regulators of bone remodelling. In vitro osteocyte models are currently limited to cell lines in monolayer, but these do not represent their 3D environment in vivo. We have recently shown that osteoblasts in 3D gels differentiate along the osteocytic pathway. Since retinoic acid (RA) has been shown to stimulate monolayer osteoblast/osteocyte differentiation, we have inv...