Searchable abstracts of presentations at key conferences in endocrinology

ea0011p911 | Thyroid | ECE2006

Problems of identifying independent non-class II susceptibility loci within the HLA region for Graves’ disease

Simmonds MJ , Heward JM , Franklyn JA , Gough SCL

The HLA class II region, in particular DRB1/DQA1/DQB1, has been consistently associated with Graves’ disease (GD) for over thirty years. Only recently has work within our own group made progress in narrowing down the etiological variant(s) present within DRB1/DQA1/DQB1, by excluding DQB1, and by mapping association at DRB1 to nine amino acid positions present within the peptide binding domain, with position β74 being the most associated. Independ...

ea0011p850 | Thyroid | ECE2006

Association of the FCRL3 gene with Graves’ disease in the UK Caucasian population

Simmonds MJ , Heward JM , Carr-Smith J , Franklyn JA , Gough SCL

Recently, linkage between chromosome 1q23 and rheumatoid arthritis within the Japanese population has been narrowed down to association of four single nucleotide polymorphisms (SNPs), fcrl3_3, fcrl3_4, fcrl3_5 and fcrl3_6, within FCRL3, a known regulator of B cell signalling. Of these four SNPs, fcrl3_3 was shown to disrupt FCRL3 expression on B cells, suggesting a potential etiological role. Association of fcrl3_3 was also replicated in a Japanese Graves’ disease ...