Searchable abstracts of presentations at key conferences in endocrinology

ea0011p378 | Diabetes, metabolism and cardiovascular | ECE2006

SiRNA-mediated depletion of synaptotagmin-11 abrogates insulin-stimulated glucose uptake in 3T3-L1 adipocytes

Miller SCM , Mitra P , Connell JMC , Gould GW

The fusion of insulin-stimulated GLUT4-containing vesicles (GSV) with the plasma membrane (PM) of adipose or skeletal muscle cells is governed by regulated exocytosis. In all such membrane fusion events cognate t- and v-SNAREs interact in an ordered way to allow vesicles to first dock with, and then fuse with the plasmalemma. In neurons, the best-studied example of this well conserved process, the protein species responsible for directing the final (rate-limiting) fusion step ...