Searchable abstracts of presentations at key conferences in endocrinology

ea0022p546 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Plasma agouti-related peptide (AgRP) levels in male patients with hypogonadotropic hypogonadism

Demirci Hakan , Yonem Arif , Gozum Gunay , Ozata Metin

Objective: Agouti related peptide (AgRP), the endogenous antagonist of the melanocortin 3 and 4 receptors, is expressed at high levels in the arcuate nucleus of the hypothalamus. Some studies have demonstrated that intracerebroventricular AgRP administration increases plasma LH, FSH, testosterone levels. It also increases hypothalamic LHRH release in vitro, an effect that can be prevented by addition of melanocyte stimulating hormone. These findings suggest that AgRP ma...