Searchable abstracts of presentations at key conferences in endocrinology

ea0016p27 | Adrenal | ECE2008

Modulation of adrenocortical aldosterone and cortisol synthesis by in vitro oxidized low density lipoprotein

Kopprasch Steffi , Ansurudeen Ishrath , Graessler Juergen , Bornstein Stefan R , Pietzsch Jens

Objectives: Oxidative stress is of critical importance in the pathogenesis of endocrinopathies. Since cholesterol serves as a major source of steroid hormone synthesis we investigated the effect of hypochlorite-modified low density lipoprotein (LDL) on aldosterone and cortisol release from human adrenocortical NCI-H295R cells.Methods: Native LDL obtained from healthy volunteers was oxidized to varying degrees by sodium hypochlorite. The resulting modifie...