Searchable abstracts of presentations at key conferences in endocrinology

ea0014p575 | (1) | ECE2007

The GH releasing activity of ghrelin is insensitive to the negative growth hormone (GH) autofeedback in humans

Riganti Fabrizio , Prodam Flavia , Gramaglia Elena , Benso Andrea , Lucatello Barbara , Ghigo Ezio , Broglio Fabio

Growth hormone (GH) secretion is regulated by a complex interplay between GH-releasing hormone (GHRH), somatostatin and several other central and peripheral modulatory signals. Ghrelin has been hypothesized as physiological amplifier of GH pulsatility and acts via mechanisms, at least partially, independent of GHRH and somatostatin. The GH response to GHRH is strongly inhibited by previous administration of recombinant human GH (rhGH), likely as a consequence of a somatostatin...

ea0026p710 | Diabetes (epidemiology, pathophysiology) | ECE2011

Continuous glucose monitoring enhances the diagnostic value of mixed meal test in reactive hypoglycemia

Olivetti Ilaria , Grassi Giorgio , Lambertenghi Veronica , Tomelini Michela , Gigliardi Valentina Ramella , Gramaglia Elena , Ghigo Ezio , Broglio Fabio

Background: Clinical reactive hypoglycemic events are defined as the coexistence of plasma glucose <60 mg/dl and autonomic and/or neuroglycopenic symptoms occurring in fed conditions. The diagnosis is based on tests aiming to simulate the causative triggers (i.e. mixed meal test). In clinical practice, however, a high percentage of symptomatic patients results negative to such diagnostic approach, leading to the impression of an inadequate sensitivity of this diagnostic to...

ea0020oc4.5 | Acromegaly/IGF1/Type 2 Diabetes | ECE2009

Regulation of obestatin levels during unacylated ghrelin infusions in normal and type 2 diabetic patients

St-Pierre David H , Settanni Fabio , Olivetti Ilaria , Gramaglia Elena , Benso Andrea , Riganti Fabrizio , Ghigo Ezio , Broglio Fabio

Background: Obestatin, a ghrelin gene product was recently isolated but important questions remain regarding its regulation and its physiological effects. The aim of the present study was to evaluate the effect of unacylated ghrelin (UAG) on obestatin levels in normal subjects and patients with type 2 diabetes (T2D).Methods: Five normal subjects and 5 T2D patients were included in this study. Unacylated ghrelin (3 μg/kg per hour) or saline were cont...

ea0020p117 | Thyroid | ECE2009

Subjective and objective sleep evaluation in patients with hypo- and hyper-thyroidism

Riganti Fabrizio , Noi Fabiana Di , Seardo Maria Angela , Gramaglia Elena , Bonelli Nadia , Rossetto Ruth , Ghigo Ezio , Broglio Fabio

Hyper- and hypo-thyroidism are considered as clinical conditions of sleep alterations. At present, however, these clinical reports have never been confirmed by studies providing a structured description of subjective and objective sleep quantity and quality. To this aim, we enrolled 15 patients with naïve overt hyperthyroidism (HYPER), 9 with naïve overt primary hypothyroidism (HYPO) and 15 healthy age-, sex- and BMI-matched control subjects (CS). Clinical conditions...

ea0020p439 | Obesity and Metabolism | ECE2009

The evaluation of metabolic effects following ghrelin and salbutamol administration

Benso Andrea , St-Pierre David H , Gramaglia Elena , Riganti Fabrizio , Lucatello Barbara , Olivetti Ilaria , Ghigo Ezio , Broglio Fabio

Background: The activation of the GHS-R1a receptor by acylated ghrelin (AG) or by synthetic GH secretagogues (GHS), potently stimulates GH release and mediates other neuroendocrine/metabolic effects. Beta-adrenergic receptor agonists negatively influence GH secretion and other metabolic functions. The GH response to AG and GHS is refractory to the inhibitory effect of β2-adrenoceptors activation but no other report has evaluated the interactions between AG and salbutamol ...

ea0016p532 | Obesity | ECE2008

Diabetogenic effects of a continuous infusion of acylated ghrelin in normal and type 2 diabetic patients

St-Pierre David H , Olivetti Ilaria , Pomero Elisa , Gramaglia Elena , Riganti Fabrizio , Benso Andrea , Ghigo Ezio , Broglio Fabio

Background: Previous studies have shown that acylated ghrelin (AG) modulates insulin secretion and glucose disposal in vitro and after acute administration in humans. The aim of the present study was to evaluate postprandial glucose and insulin response following AG infusion in normal subjects and patients with type 2 diabetes.Methods: Six normal subjects and 3 patients with type 2 diabetes were included in this study. AG (1 μg/kg per h) or s...

ea0014p79 | (1) | ECE2007

Unacylated ghrelin (UAG) enhances the early insulin response to meal, improves glucose metabolism and decreases free fatty acids levels in healthy volunteers

Prodam Flavia , Riganti Fabrizio , Gramaglia Elena , Benso Andrea , Lucatello Barbara , Broglio Fabio , Abribat Thierry , Jan van der Lely Aart , Ghigo Ezio

Ghrelin circulates in two different forms. Acylated ghrelin (AG), a natural ligand of the GH Secretagogue receptor (GHS-R) type 1a, exerts several biologic central and peripheral actions including stimulation of GH secretion, but also modulation of insulin secretion, glucose and lipid metabolism. Unacylated ghrelin (UAG), despite unable to bind the GHS-R1a, is biologically active showing some influence in vitro and in vivo on glucose and lipid metabolism likely m...

ea0014p561 | (1) | ECE2007

Effects of CST-8, a synthetic cortistatin analogue, in humans

Benso Andrea , Prodam Flavia , Gramaglia Elena , Riganti Fabrizio , Lucatello Barbara , Jan van der Lely Aart , Deghenghi Romano , Muccioli Giampiero , Ghigo Ezio , Broglio Fabio

Cortistatin (CST), a neuropeptide with high structural homology with somatostatin (SS), binds all SS receptor (SS-R) subtypes but, unlike SS, also shows high binding affinity to ghrelin (GRLN) receptor (GRLN-R). In humans CST exerts the same endocrine activities of SS, suggesting that the activation of the SS-R might mask the potential interaction with the GRLN system.CST-8, a synthetic CST-analogue devoid of any binding affinity to SS-R but capable to b...