Endocrine Abstracts

Scrotal color-doppler ultrasonography (sCDUS) and transrectal ultrasonography (trCDUS) provide crucial information about the clinical status of testes and male accessory glands. However, the US evaluation of the infertile male is still often considered as a second level diagnostic tool. To analyze the role of ultrasound in male infertility, in order to predict hypothalamic-pituitary-testicular axis function, 1120 records from infertile men were retrospectively evaluated (from ...

Human seminal plasma contains a large array of proteins required for the normal physiology of spermatozoa and fertilization. To provide informations about the physiological mechanisms of male fertility we performed proteomic studies on human seminal plasma by a top-down approach. A semen sample was collected in a fertile normospermic man (sperm concentration 60×106 per ml; progressive motility 58%; normal morphology 45%). Hormonal blood assay was performed: tes...

The chemical composition of the cervical mucus (CM), its physical characteristics and the volume secreted show cyclical changes during the menstrual cycle.Clinical proteomics has recently developed new technologies and bioinformatics useful in identifying molecular markers of physiology and pathology. The development of novel mass spectrometers, like the LTQ-Orbitrap, considerably contributed to increase the quantity of acquired data. Aim of the present ...

The IGF1 response to recombinant human growth hormone (rhGH) showed some individual variability and the responsible factors for this behavior remain unknown. Some studies have emphasized the possible role of isoforms of the GH receptor (GHR), showing conflicting results.Therefore, we investigated the possible influence of the isoforms of the GHR to the diagnosis of GHD and in determining adult hormone replacement therapy responsiveness.<p class="abst...

Pituitary transforming gene 1 (PTTG1) is a mammalian securing involved in mitosis to ensure chromosomal stability. PTTG1 is overexpressed in a variety of tumors. It can directly and indirectly induce expression of genes that are involved in regulating tumorigenesis and cancer development (c-Myc, bFGF, VEGF and MMP2).We evaluated PTTG1-expression by immunohistochemistry on formalin-fixed and paraffin-embedded specimen testicular tissues from 53 male patie...

Oxidative stress is associated with chronic alcoholic abuse; it is also a mechanism involved in male infertility. To further investigate the relationships between these two conditions, we studied 6 patients with diagnosis of Alcohol Dependence (DSM-IV) during post-detoxification phase, who consulted our centre for infertility. We evaluated seminal parameters, hormone pattern, Total Antioxidant Capacity (TAC) and the lipophilic antioxidant Coenzyme Q10 (CoQ10), both in blood an...

Endometriosis is a chronic gynecological inflammatory disease characterized by the presence of functional endometrial glands and stroma outside of the uterine cavity. It affects 7–10% of women of reproductive age, up to 50% of women with infertility and up to 60% of women with dysmenorrhea. The aim of this pre-clinical study was evaluate the efficacy of low-dose SKA Progesterone (GUNA) and low-dose SKA IL-10 (GUNA) in the modulation of the inflammatory response in endomet...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominantly inherited endocrine tumor syndrome characterized by development of cancer in various endocrine organs, particularly in pituitary, parathyroid and pancreas. Moreover, in some cases, also non-endocrine tumors can be diagnosed, developing atypical phenotypes.Case report: We report herein the clinical history of a patient affected by MEN-1 syndrome who developed atypical feat...