Searchable abstracts of presentations at key conferences in endocrinology

ea0041oc2.2 | Receptors & Signalling | ECE2016

Expression levels of thyroglobulin processing proteases are reduced upon trace amine-associated receptor 1 deficiency in mice

Szumska Joanna , Batool Zaina , Qatato Maria , Gavilanes Emily Melisa Ullrich , Skripnik Vladislav , Shillova Nita , Grandy David K. , Brix Klaudia

The function of the thyroid gland is to maintain thyroid hormone (TH) levels in the blood circulation. Thyroid epithelial cells liberate TH from the precursor molecule thyroglobulin (Tg) by the combined proteolytic action of the cathepsin B, K, L, and S. Cathepsin L-deficiency in mice results in impaired processing of Tg and remnants of dead cells in the follicle lumen. Recently, we have shown that Trace amine-associated receptor 1 (Taar1) is localized on the primary cilia of ...

ea0014oc10.6 | Obesity & metabolism | ECE2007

3-Iodothyronamine (T1AM) is a novel modulator of metabolic rate and glucose homeostasis

Grandy David K. , Suchland Katherine L. , Keck Thomas M. , Yan Feifei , Shyng Show-Ling , Scanlan Thomas S.

3-Iodothyronamine (T1AM) is a novel endogenous derivative of thyroid hormone (TH), recently described by Scanlan et al. (Nat. Med. 10: 638, 2004). In vitro, T1AM can stimulate the production of cAMP via activation of a heterologously expressed G protein-coupled receptor (GPCR) now referred to as trace amine-associated receptor 1 (TAAR1; Lindemann et al. Genomics 85: 372, 2005). In adult, unanesthetized C57Bl6/J mice, T1AM produces prof...