Searchable abstracts of presentations at key conferences in endocrinology

ea0081oc8.4 | Oral Communications 8: Calcium and Bone | ECE2022

Is the “rebound phenomenon” following Denosumab discontinuation a risk factor for Zoledronic acid acute phase adverse reactions?

Zampogna Marta , Grassi Giorgia , Ghielmetti Alberto , Palmieri Serena , Arosio Maura , Vainicher Cristina Eller

Background: Zoledronic acid (ZOL) administration may cause acute phase adverse reactions (APR), which manifest with fever, malaise, bone and muscular pain, headache and/or gastrointestinal disturbances. Previous data suggest that high N-terminal propeptide of type 1 collagen (P1NP) and low 25, OH-vitaminD (VitD) levels are associated with higher incidence of APR, while the previous use of bisphosphonates is a protective factor. Lately, ZOL has been frequently used to mitigate ...

ea0081p558 | Calcium and Bone | ECE2022

Clinical and biochemical response to Burosumab treatment in two patients with X-linked hypophosfatemic rickets and tertiary hyperparathyroidism

Ghielmetti Alberto , Zampogna Marta , Palmieri Serena , Grassi Giorgia , Rosa Caruso Maria , Arosio Maura , Vainicher Cristina Eller

Introduction: in X-linked hypophosfatemic rickets (XLH) mutations of PHEX lead to elevated FGF-23 levels. Phosphate salts and calcitriol represented the only treatment option. Tertiary hyperparathyroidism (THPT) is a complication of XLH worsening the clinical features and constituting a contraindication to conventional treatment. Burosumab, a monoclonal antibody anti-FGF23, was recently approved in XLH. No data about Burosumab treatment in patients with XLH and THPT are availa...

ea0063gp237 | Anterior and Posterior Pituitary | ECE2019

Diagnostic accuracy of copeptin in the diagnosis of diabetes insipidus after pituitary surgery

Ferrante Emanuele , Serban Andreea , Sala Elisa , Cremaschi Arianna , Grassi Giorgia , Locatelli Marco , Arosio Maura , Mantovani Giovanna

Background: Routine clinical use of arginine-vasopressin (AVP) is limited by its small molecular size and pre-analytical errors. In contrast, copeptin – a peptide of 39 amino acids co-secreted with arginine-vasopressin (AVP) - is a stable protein and its measurement represents a reliable measure of AVP concentration. The aim of this study was to analyze diagnostic role of copeptin in diagnosis of diabetes insipidus (DI) in patients treated for hypothalamic-pituitary disea...

ea0070aep134 | Bone and Calcium | ECE2020

Radiofrequency Echographic Multi Spectrometry (REMS) evaluation in patients with primary osteoporosis and primary hyperparathyroidism

Grassi Giorgia , Palmieri Serena , Cairoli Elisa , Chiodini Iacopo , Arosio Maura , Eller Vainicher Cristina

Background: Radiofrequency Echographic Multi Spectrometry (REMS) is a new ultrasound-based tool for bone mineral density (BMD) measurement, recently approved by FDA for the use in clinical routine to diagnose osteoporosis (OP) and to monitor bone changes. However, data on patients with secondary OP are not available. The aim of our study was to compare REMS and DXA ability in identifying clinical (cFX) and morphometric vertebral fractures (VFx) in patients with primary OP (pOP...

ea0073oc6.4 | Oral Communications 6: Calcium and Bone | ECE2021

Bisphosphonates after Denosumab withdrawal reduce the vertebral fractures incidence

Grassi Giorgia , Chiodini Iacopo , Palmieri Serena , Cairoli Elisa , Arosio Maura , Eller Vainicher Cristina

ObjectiveSeveral studies showed that patients discontinuing denosumab (Dmab) may experience bone loss and incident vertebral fractures (VFx) due to a rebound bone turnover increase, suggesting the need of anti-resorptive (i.e. bisphosphonate BPs) therapy to mitigate this occurrence. However, the morphometric VFx (morphoVFx) incidence after Dmab discontinuation is unknown and scarce data are available about the BPs effect on BMD changes and Fx risk in thi...

ea0063p790 | Thyroid 2 | ECE2019

The prevalence of macro TSH in patients with subclinical hypothyroidism: experience of a single centre

Serban Andreea , Ferrante Emanuele , Maregnani Alessio , Grassi Giorgia , Mantovani Giovanna , Beck-Peccoz Paolo , Ceriotti Ferruccio , Arosio Maura

Background: Subclinical hypothyroidism (SH) is a frequent clinical condition with a prevalence of 3–15% in general population. It is defined by elevated TSH levels with normal thyroid hormones [free thyroxine (FT4) and free triiodothyronine (FT3)]. Similar to prolactin, high TSH levels may be caused by macroTSH, a large molecular sized TSH with a low bioactivity. The aim of the study was to assess the prevalence of macroTSH in patients with subclinical hypothyroidism....

ea0056p860 | Pituitary - Clinical | ECE2018

Mind the gap between cortisol levels measured with second generation assays and current diagnostic thresholds for the diagnosis of adrenal insufficiency: a single center experience

Grassi Giorgia , Morelli Valentina , Polledri Elisa , Fustinoni Silvia , Chiodini Iacopo , Ceriotti Ferruccio , D'Agostino Simona , Mantovani Giovanna , Arosio Maura

Objective: The current cut-offs to diagnose adrenal insufficiency (AI) have been established using outdated immunoassays. More modern methods have demonstrated less cross-reactivity with other steroids. The aim of our study was to evaluate the correlation between the cortisol assay Roche Cortisol I (R1), the newly available Roche Cortisol II (R2) and liquid chromatography tandem mass spectrometry (LC-MS/MS), the gold standard procedure for the measurement of steroids.<p cl...

ea0081p307 | Calcium and Bone | ECE2022

Impact of underlying disease on long-term skeletal outcome after lung transplantation

Grassi Giorgia , Chiodini Iacopo , Cairoli Elisa , Corinna Morlacchi Letizia , Rossetti Valeria , Rosso Lorenzo , Righi Ilaria , Nosotti Mario , Arosio Maura , Blasi Francesco , Eller Vainicher Cristina

Background: fragility fractures (FX) occur frequently after lung transplantation (TX), with a higher rate (15-20%) in the first two years, which decreases subsequently. Patients affected from cystic fibrosis (CF) seem to have a lower FX risk in the first two years after TX as compared with those affected with other lung diseases (nCF). The aim of our study is to evaluate and compare the long-term skeletal outcome in CF and nCF patients after TX.Methods: ...

ea0063p322 | Reproductive Endocrinology 1 | ECE2019

Assessment of biochemical hyperandrogenism in PCOs by liquid chromatography tandem mass spectrometry using a multisteroid kit: focus on testosterone and androstenedione

Grassi Giorgia , Morelli Valentina , Polledri Elisa , Fustinoni Silvia , Chiodini Iacopo , Ceriotti Ferruccio , D'Agostino Simona , Filippi Francesca , Somigliana Edgardo , Mantovani Giovanna , Arosio Maura

Objective: The identification of hyperandrogenism represents the cornerstone for the assessment of polycystic ovary syndrome (PCOs). However, its definition has always been troubling, mostly because of the poor accuracy shown by routine androgens assays. As suggested by literature, the application of more precise steroid measurement methods (such as liquid chromatography tandem mass spectrometry, LC-MS/MS) could improve the diagnostic workup. The aim of our study is to evaluat...