Searchable abstracts of presentations at key conferences in endocrinology

ea0016p519 | Obesity | ECE2008

In the metabolic syndrome adrenergic overdrive is independent on the obese state

Colombo Manuela Carla , Quarti-Trevano Fosca , Dell'Oro Raffaella , Gamba Pierluigi , Arenare Francesca , Perego Rita , Ilardo Valeria , Grassi Guido , Mancia Giuseppe

Objective: The metabolic syndrome (MS) is characterized by a marked sympathetic activation. Whether this adrenergic overdrive is mainly dependent on the obese state or it can be detected also in absence of obesity is unknown, however.Design and Methods: In 25 male patients (age 41.4±yrs., mean±S.E.M.) with MS (ATP III criteria) and in 12 age-matched healthy male controls, we measured body mass index (BMI), waist circumference (WC...

ea0032p865 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effects of somatostatin analogues on muscle sympathetic nerve activity in acromegaly

Carzaniga Chiara , Seravalle Gino , Attanasio Roberto , Grassi Guido , Cozzi Renato , Maria Fatti Letizia , Montini Marcella , Vitale Giovanni , Sciortino Giovanna , Damanti Sarah , Scacchi Massimo , Mancia Giuseppe , Cavagnini Francesco , Persani Luca

Introduction: While searching for mechanisms contributing to the increased mortality of acromegaly, we have previously described an unexpected sympathoinhibition in newly diagnosed patients (Seravalle et al., Clin Endocrinol 77:262, 2012) and interpreted this finding as an adaptive phenomenon. It has also been shown that centrally administered somatostatin (SS) inhibits peripheral sympathetic outflow in rodents (Rettig et al., Am J Physiol 257:R588, 1989). Ba...