Searchable abstracts of presentations at key conferences in endocrinology

ea0005p234 | Steroids | BES2003

Aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) gene expression in the normal and failing rat heart

Millar C , Ye P , Gray G , Wallace A , MacKenzie S , Fraser R , Connell J , Davies E

Aldosterone synthase and 11beta-hydroxylase catalyse the final steps of glucocorticoid (corticosterone) and mineralocorticoid (aldosterone) production in the rat adrenal cortex. They are encoded by the CYP11B2 and CYP11B2 genes respectively. Recent studies have shown that CYP11B1 and CYP11B2 are also expressed in the brain, the vascular system and the heart where it has been suggested that aldosterone influences cardiac function and plays a role in cardiac fibrosis. However, i...