Endocrine Abstracts

Pre-eclampsia is a life-threatening disease occurring in 4.6% of pregnancies characterised by multi-organ dysfunction. Placental dysfunction is implicated with release of factors causing systemic inflammation and endothelial dysfunction. Mild hyponatraemia (130–135 mmol/l) is regarded as physiological in normal pregnancy. Severe hyponatraemia (<125 mmol/l) is a rare life-threatening complication of pre-eclampsia. Severe hyponatraemia and hyperkalaemia has been reporte...

Primary hyperparathyroidism is a common cause of hypercalcaemia increasing in prevalence with age peaking in females at 70-90 years of age (492 cases/100,000 population) and in males above 80 years of age (264 cases/100,000 population). Immobilisation hypercalcaemia is regarded as an uncommon non-parathyroid hormone dependent cause of hypercalcaemia typically occurring in young patients with spinal cord injuries and neuromuscular disorders. It is of complex physical and molecu...