Searchable abstracts of presentations at key conferences in endocrinology

ea0063p259 | Pituitary and Neuroendocrinology 1 | ECE2019

Neural network for predicting recurrence of the Cushing’s disease within three years after neurosurgical treatment

Nadezhdina Elena , Rebrova Olga , Grigoriev Andrey

Introduction: The reccurence rate after successful neurosurgery for patients with Cushing’s disease (CD) varies between 10% and 65%. It is shown earlier that some features are associated with the probability of recurrence, yet no rules were elaborated how to analyse the set of variables.Materials and methods: The retrospective study was based on 219 cases of CD (32 men, 187 women) with a disease duration ranged from 4 months to 22 years, who underwe...

ea0063p270 | Pituitary and Neuroendocrinology 1 | ECE2019

Assessment of endocrine function before and after transsphenoidal surgery for Cushing s disease

Kolesnicova Galina , Arapova Svetlana , Marova Evgenia , Grigoriev Andrey

It is known that disoaders of the hypothalamic-pituitary-adrenal system and excess glucocorticoids in Cushing’s disease (CD) can significantly affect various organs and systems, in particular, the secretion of pituitary hormones. However, in the literature there is practically no work on the assessment of the state of tropic hormones and hormones of the peripheral glands in the early postoperative period after transsphenoidal adenomectomy. The aim of this study was to ass...

ea0049ep917 | Neuroendocrinology | ECE2017

Predictors of remission after transsphenoidal adenomectomy in patients with Cushing’s disease

Marova Eugenia , Kolesnicova Galina , Arapova Svetlana , Grigoriev Andrey , Lapshina Anasteysa

Abstract: Cushing’s disease (CD) is the heavy disease of the hypothalamic–pituitary–adrenal axis. The cause of the disease is pituitary adenoma (corticotropinoma). Hypersecretion of ACTH by a pituitary adenoma leads to increased secretion of cortisol by the adrenal cortex and the development of total endogenous hypercortisolism. The gold standard treatment for this disease is surgical removal of corticotropinoma. However, adenomectomy is not effective in all cas...

ea0041ep267 | Clinical case reports - Pituitary/Adrenal | ECE2016

«Clinically silent» somatotropinoma

Lipatenkova Anna , Dzeranova Larisa , Pigarova Ekaterina , Grigoriev Andrey

Introduction: Somatotropinomas are typically recognized when GH excessively secretion causes acromegaly. «Silent» somatotroph adenomas (immunohistochemical evidence of GH excess without biochemical or clinical evidence) and «clinically silent» somatotroph adenomas (immunohistochemical and biochemical evidence without clinical evidence) have occasionally been reported. The relative frequency of each presentation is unknown.<p class="abst...

ea0037ep1171 | Clinical Cases–Pituitary/Adrenal | ECE2015

Three cases of successful pregnancy outcomes after different methods of therapy in women of acromegaly apart from remission of the disease

Molitvoslovova Natalia , Grigoriev Andrey , Trunin Yuri , Oleynik Olga

Reports of pregnancy in acromegalic women are uncommon.Case 1: Patient K., 25-year-old., 01/04/2008 – transsphenoidal adenomectomy in connection with active acromegaly (GH/OGTT – 47.2–64.0–38.0–29.6–28.7 ng/ml; macroadenoma 19×14×12 mm with compression of optic chiasm). Postoperative remission of the disease, recovery of menstrual function without additional therapy. At the end of August 2008 the patient became pre...

ea0020p598 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Central diabetes insipidus after transsphenoidal treatment for tumors of the sellar region: prognostic factors for transient course of the disease

Pigarova Ekaterina , Rozhinskaya Liudmila , Grigoriev Andrey , Dzeranova Larisa

Central diabetes insipidus (CDI) is a common complication after transsphenoidal treatment for tumors of the sellar region and may exhibit different patterns: transient, permanent or triphasic.The aim of our study was to determine the incidence and course of the CDI and to characterize the factors associated with resolution of this disease.The incidence of CDI was based on records of 318 patients who underwent transsphenoidal surger...

ea0014p132 | (1) | ECE2007

Results of treatment of patients with pituitary somatotroph adenomas

Grigoriev Andrey , Molitvoslovova Natalye , Kolesnikova Galina , Kuzmin Anatolij

In ESC for the period since October 2004 till October 2006 were operated 69 patients with acromegaly. Men were 22 (32%), women – 47 (68%). Age of patients changed from 24 till 68 (middle – 47).All patients were separated into 2 groups: surgery (group 1) and combination treatment (group 2), which consist of surgery and somatostatin analogues therapy before and after surgery.In most cases were macroadenomas, only 5 patients...

ea0056p747 | Neuroendocrinology | ECE2018

The probability of recurrence of the Cushing’s disease within three years after surgical treatment depends on the ACTH and cortisol levels in early post-surgery period

Nadezhdina Elena , Rebrova Olga , Ivaschenko Oksana , Azizyan Vilen , Grigoriev Andrey

Objective: The search for the predictors of the Cushing’s disease (CD) recurrence after surgical treatment among the following parameters - gender, age, adenoma size, preoperative levels of ACTH (morning) and cortisol (evening) in the blood, postoperative levels of ACTH (morning) and cortisol (morning) in the blood.Material and methods: A retro- and prospective monocenter study of treatment outcomes in 181 patients with confirmed diagnosis of Cushin...

ea0081ep724 | Pituitary and Neuroendocrinology | ECE2022

Short-term and long-term surgical remission of acromegaly in a tertiary medical center

Lutsenko Alexander , Belaya Zhanna , Przhiyalkovskaya Elena , Rozhinskaya Liudmila , Grigoriev Andrey , Azizyan Vilen , Melnichenko Galina

Background: Surgical outcomes in patients with acromegaly are highly dependent on a surgeon’s level of expertise, as the majority of patients present with macroadenomas at diagnosis.Aim: To assess remission rates in patients with acromegaly admitted to a tertiary medical center.Materials and methods: We included patients admitted to the neuroendocrinology and bone disease department with no previous radiation therapy or curren...

ea0049gp157 | Neuroendocrinology &amp; Growth Hormones | ECE2017

Predictors of permanent, transient and three-phase postoperative diabetes insipidus

Mikhaylova Daria , Dzeranova Larisa , Pigarova Ekaterina , Rozhinskaya Ludmila , Grigoriev Andrey , Azizyan Vilen , Ivashenko Oksana

Objectives: To evaluate predictors of permanent, transient and three-phase diabetes insipidus (DI) in patients undergoing endoscopic endonasal transsphenoidal surgery.Patients and methods: The study included 154 patients undergoing endoscopic endonasal transsphenoidal surgery (122 women and 32 men) age from 18 to 65 years (median 40 (31;52)). 73 patients with Cushing disease, 66 patients with acromegaly, four patients with prolactinomas, nine patients wi...