Searchable abstracts of presentations at key conferences in endocrinology

ea0021oc4.3 | Bone and parathyroid | SFEBES2009

Mice deleted for the transcription factor Gata3 have fewer parathyroid cells expressing Gcm2, develop hypocalcaemia and have an earlier onset of mortality when challenged with a low calcium-vitamin D diet

Grigorieva Irina , Mirczuk Samantha , Gaynor Katie , Nesbit M Andrew , Grigorieva Elena , Wei Qiaozhi , van der Wees Jacqueline , Fraser William , Hough Tertius , Manley Nancy , Grosveld Frank , Thakker Rajesh

Heterozygous mutations of GATA3, a dual zinc-finger transcription factor, cause the hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome. To study the role of GATA3 in parathyroid function we have investigated Gata3+/− mice for hypoparathyroidism. Gata3+/− and Gata3+/+ mice were challenged at weaning with a diet low in calcium (0.001%) and vitamin D (0.0 IU/g). The low calcium-vitamin D diet led to a ...

ea0013p10 | Bone | SFEBES2007

Calcium homeostasis and parathyroid function in Gata3 knockout mice: relevance to the human hypoparathyroidism, deafness and renal dysplasia syndrome

Grigorieva Irina , Harding Brian , Nesbit M Andrew , Fairclough Rebecca , Grigorieva Elena , Ali Asif , Hough Tertius , Fraser William , van Wees Jaqueline , Grosveld Frank , Thakker Rajesh

The Hypoparathyroidism, Deafness and Renal dysplasia (HDR) syndrome is an autosomal dominant disorder caused by mutations in the dual zinc-finger transcription factor GATA-3. Gata3 heterozygous (+/−) knockout mice develop deafness, while Gata3 homozygous (−/−) mice, which are embryonically lethal at 11.5 to 12.5 days post-coitum (dpc), develop renal hypoplasia. The parathyroids have not been studied, and we therefore investigated these mice for ...