Searchable abstracts of presentations at key conferences in endocrinology

ea0014p7 | (1) | ECE2007

Effects of melatonin on glutathione peroxidase activity after adriamycin in normal and pinealectomized rats

Dabrowska Katarzyna , Stuss Michal , Gromadzinska Jolanta , Wasowicz Wojciech , Sewerynek Ewa

Adriamycin (ADR) is a potent chemotherapeutic agent, effective in treatment of leukemias, lymphomas and of many solid tumours. However, its clinical usage is often limited by cardiotoxicity, induced by oxygen radical damage of membrane lipids.Melatonin (MEL), is a well-known antioxidant. It has been shown that melatonin can scavenge free radicals, both directly or indirectly, stimulating the activity of antioxidative enzyme, e.g., glutathione peroxidase ...