Searchable abstracts of presentations at key conferences in endocrinology

ea0022oc5.4 | Reproduction & Thyroid | ECE2010

One hormone, two functions: the chorionic gonadotropin in New World Monkeys

Adams Christian , Henke Alexander , Gromoll Jorg

Objective: The LH and chorionic gonadotropin (CG) are essential for reproduction and male sexual development. While LH induces tesosterone production, CG is essential for the establishment of pregnancy. In the New World Monkeys (NWM) the initial duplication of the ancestral LH-beta subunit (LHB) gene, which gave rise to the novel CG-beta subunit (CGB) gene, was followed by a genomic rearrangement event, leading to CGB expression in pituitary and placenta, whereas LHB became a ...

ea0014s11.1 | Polycystic ovary syndrome | ECE2007

The CAG repeat polymorphism of the androgen receptor gene is an independent risk factor for polycystic ovary syndrome (PCOS)

Schuering Andreas , Jurgens Andrea , Gromoll Jorg , Zitzmann Michael , Sonntag Barbara , Nieschlag Eberhard , Greb Robert , Kiesel Ludwig

Introduction: Polycystic ovary syndrome (PCOS) is a frequent disorder with a variable phenotype and a suspected genetic background. Androgenic effects constitute the central mechanism for the clinical, biochemical and sonographic features of PCOS. Androgenic effects are transported by the androgen receptor, whose activity can be modulated by a genetic polymorphism. We investigated the role of the CAG repeat polymorphism of the androgen receptor in PCOS.P...

ea0032p577 | Female reproduction | ECE2013

The hinge region of the lutropin receptor mediates different activation mechanisms: CG induces trans- and LH only cis-initialization

Grzesik Paul , Kreuchwig Annika , Teichmann Anke , Furkert Jens , Rutz Claudia , Wiesner Burghard , Kleinau Gunnar , Schulein Ralf , Gromoll Jorg , Krause Gerd

The lutropin receptor (LHR) is associated with reproduction and becomes activated by choriogonadotropin (CG) or lutropin (LH) resulting in different physiological functions with regard to differing signaling cascades. The underlying mechanisms in receptor/hormone interaction are not yet understood. CG is known to induce trans-activation at LHR oligomers (activates a second receptor), but details of LH mechanisms were not clarified yet.To study this issue...