Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp3 | Adrenal and Neuroendocrine - Tumour | ECE2019

ProGRP is an effective marker for disease monitoring in lung carcinoids with non-informative chromogranin A: Lessons from clinical practice

Oleinikov Kira , Grozinsky-Glasberg Simona , Gross David J , Nechushtan Hovav , Peretz Tamar , Maimon Ophra , Nisman Beni

Introduction: The histologic classification of lung carcinoids (LCs) as typical (TCs) and atypical (ACs) highlights its role as major prognostic factor for these patients. However, in the absence of sensitive biomarkers to effectively predict tumor behavior, long-term imaging surveillance is recommended for disease monitoring. Limited data suggest that progastrin-releasing peptide (ProGRP) may have diagnostic & monitoring utility in LCs.Aim(s): To ev...

ea0063p12 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Combined autophagy and mTOR inhibition reduces cells proliferation and induces apoptosis in a lung carcinoid in-vitro model

Knigin Adi , Avniel-Polak Shani , Gross David J , Grozinsky-Glasberg Simona

Introduction: Treatment options for patients with metastatic lung carcinoids (LC) are limited. Everolimus (RAD001), an mTOR inhibitor (mTORi) which suppresses tumor cells growth & proliferation, appears to be efficient in these patients; however, it promotes autophagy, thereby paradoxically supporting tumor cell survival and development of drug-resistance. We have previously demonstrated in a BON1 pancreatic NEN model that adding chloroquine (CQ, an autophagy inhibitor) to...

ea0049ep1391 | Thyroid (non-cancer) | ECE2017

The impact of age and gender on the presentation and prognosis of medullary thyroid cancer – an Israeli multicenter study

Twito Orit , Grozinsky-Glasberg Simona , Benbassat Carlos , Llevy Sigal , Bachar Gideon , Gross David J , Hirsch Dania

Background: Data regarding the effect of gender and age on medullary thyroid cancer (MTC) presentation and prognosis is limited. Although older age and male sex were found to correlate with poorer prognosis in some studies, this correlation may reflect differences in MTC presentation between sex and age groups, or a mixture of hereditary and sporadic MTC forms.Objective: To evaluate the impact of age and sex on the presentation and outcomes of MTC.<p...

ea0081oc14.6 | Oral Communications 14: Late Breaking | ECE2022

Engaging the Endocannabinoid System in Neuroendocrine Neoplasms (NENs) potentiates treatment outcomes and null drug resistance

Avniel- Polak Shani , Polak David , Oleinikov Kira , Gross David J , Wald Ori , Izhar Uzi , Mazeh Haggi , Drier Yotam , Glasberg Simona

Introduction: Patients with unresectable NENs are offered a variety of non-curable therapeutic options, which eventually fail due to drug resistance. Increasing evidence suggest an anticancer trait of cannabinoids, via cellular pathways including mTOR, known to be associated with drug resistance development. Still, limited data exist on the anti-cancer effects of cannabinoids in NENs.Aims: To understand the possible anti-tumor role of the cannabinoids an...

ea0049ep1374 | Thyroid (non-cancer) | ECE2017

Trends in the clinicopathological features and clinical outcomes of medullary thyroid carcinoma – an Israeli multicenter study

Hirsch Dania , Twito Orit , Levy Sigal , Bachar Gideon , Robenshtok Eyal , Gross David J , Mazeh Haggi , Benbassat Carlos

Background: The massive use of neck sonography has led to a dramatic increase in the incidence of thyroid cancer detection, predominantly small papillary carcinomas. However, changes in the presentation and course of medullary thyroid carcinoma (MTC) over time remain unclear.Objective: To evaluate trends in the presentation and outcomes of MTC.Methods: Patients treated for MTC at four medical centers in Israel were divided into two...

ea0063gp14 | Adrenal and Neuroendocrine - Tumour | ECE2019

Endoscopic ultrasound guided radiofrequency ablation (EUS-RFA) as a novel therapeutic approach in highly-selected pancreatic functioning and non-functioning neuroendocrine neoplasms (pNENs) patients: Preliminary report

Oleinikov Kira , Dancour Allain , Epshtein Julia , Benson Ariel , Mazeh Haggi , Tal Ilanit , Livovsky Dan , Goldin Eran , Gross David J , Jacob Harold , Grozinsky-Glasberg Simona

Introduction: EUS-RFA is rapidly emerging as a possible treatment alternative for patients with pNENs who are poor surgical candidates.Aim(s): To summarize our experience in terms of feasibility, safety and efficacy of EUS-RFA in a cohort of patients with functional and non-functional pNENs.Materials and methods: Retrospective case series of pNENs patients treated with EUS-RFA at two tertiary referral centers in Israel between Marc...