ea0029p1157 | Nuclear receptors and Signal transduction | ICEECE2012
Swinstead E.
, Need E.
, Grover P.
, Smith E.
, Buchanan G.
One in 11 women develop breast cancer before the age of 75, and mortality is significant. Estrogens and progesterone (PROG) are mediators of breast cancer aetiology and progression, and are targets for both diagnostics and therapy. The actions of estrogens via estrogen receptor alpha (ERĪ±) have been extensively studied, but the genomic actions of PROG via the progesterone receptor (PGR) are still not fully understood. This study investigates the genomic actions of PGR in ...