Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep803 | Nuclear receptors and Signal transduction | ECE2017

Development of novel human stable reporter cell line for the assessment of PPARγ transcriptional activity

Illes Peter , Grycova Aneta , Prichystalova Hana

Endocrine disrupting chemicals (EDCs) are exogenous compounds that affect the endocrine system, disrupt the hormonal balance and consequently cause the adverse health effects in humans. These compounds persist and accumulate in the environment and can easily gain entry to the food chain. Peroxisome proliferator-activated receptor gamma (PPARγ) and its heterodimeric partner retinoid X receptor alpha (RXRα) are very often targets of EDCs. PPARγ play crucial role i...

ea0049ep805 | Nuclear receptors and Signal transduction | ECE2017

Effects of human interleukins on transcriptional activity of vitamin D receptor in transgenic gene reporter cell lines IZ-VDRE and IZ-CYP24

Bartonkova Iveta , Grycova Aneta , Dvorak Zdenek

Vitamin D receptor (VDR) signalling can be affected with a variety of compounds, both endo- or exogenous. However, any disruption of VDR transcriptional activity can exert severe physiological or pathophysiological outcomes. It is therefore of a great importance to have a reliable in vitro screening technique that would provide a tool for efficient identification of agonists and activators of human VDR. In the current work, we described two novel human reporter cell l...