Searchable abstracts of presentations at key conferences in endocrinology

ea0016p336 | Endocrine tumours | ECE2008

G12/13-dependent growth of small cell lung cancer cells in vitro and in vivo

Buch Thomas , Grzelinski Marius , Pinkenburg Olaf , Gold Maike , Aigner Achim , Gudermann Thomas

The malignant phenotype of small cell lung cancer (SCLC) cells critically relies on the autocrine stimulation of G12/13- and Gq/11-coupled neuropeptide receptors. By this means, G12/13- and Gq/11-dependent signalling pathways are constitutively activated in these cells. While Gq/11-dependent signalling has been shown to promote proliferation of SCLC cells, the role of signalling pathways via G12/13 is still elus...