Searchable abstracts of presentations at key conferences in endocrinology

ea0063p599 | Diabetes, Obesity and Metabolism 2 | ECE2019

Testosterone restores metabolic syndrome-induced impairement in physical activity by ameliorating skeletal muscle fiber metabolism

Morelli Annamaria , Sarchielli Erica , Comeglio Paolo , Filippi Sandra , Cellai Ilaria , Guarnieri Giulia , Rastrelli Giulia , Vignozzi Linda , Maggi Mario

Background: Metabolic syndrome (MetS) is a clustering of metabolic and cardiovascular risk factors, with insulin resistance being one of the main components. In male, MetS is also associated to hypogonadotropic hypogonadism. Lifestyle modifications (e.g. physical activity) could prevent or considerably reduce MetS progression, however the ability to perform physical activity is often impaired in MetS subjects.Aim: Considering the known trophic role of T ...

ea0063p598 | Diabetes, Obesity and Metabolism 2 | ECE2019

Physical activity counteracts metabolic syndrome-induced hypogonadotropic hypogonadism and erectile dysfunction in the rabbit

Morelli Annamaria , Filippi Sandra , Comeglio Paolo , Sarchielli Erica , Cellai Ilaria , Danza Giovanna , Rastrelli Giulia , Corno Chiara , Zizza Michela , Guarnieri Giulia , Vignozzi Linda , Maggi Mario

Metabolic syndrome (MetS) clusters cardiovascular and metabolic risk factors, along with hypogonadism (HG) and erectile dysfunction (ED). Lifestyle modifications, including physical exercise (PhyEx), are well-known treatments for this condition. We previously established a non-genomic, high-fat diet (HFD)-induced rabbit model of MetS that recapitulates the human phenotype, including HG and ED. We now report studies on the effect of PhyEx on hypothalamus-pituitary-testis (HPT) ...

ea0073aep861 | Late Breaking | ECE2021

Insight on the intracrinology of menopause: androgen production within the human vagina

Cipriani Sarah , Cellai Ilaria , Di Stasi Vincenza , Comeglio Paolo , Maseroli Elisa , Todisco Tommaso , Corno Chiara , Filippi Sandra , Sorbi Flavia , Fambrini Massimiliano , Petraglia Felice , Scavello Irene , Rastrelli Giulia , Acciai Gabriele , Villanelli Fabio , Danza Giovanna , Sarchielli Erica , Guarnieri Giulia , Morelli Annamaria , Maggi Mario , Vignozzi Linda

In this study, we investigated steroidogenic gene mRNA expression in human vagina and verified the ability of human vagina smooth muscle cells (hvSMCs) to synthesize androgens from upstream precursor dehydroepiandrosterone (DHEA). As a readout for androgen receptor (AR) activation, we evaluated the mRNA expression of various androgen-dependent markers. hvSMCs were isolated from vagina tissues of women undergoing surgery for benign gynecological diseases. In these cells, we eva...