Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1004 | Growth hormone IGF axis - basic | ICEECE2012

Thyroid function during long-term GH treatment in children affected by idiopathic GH deficiency

Ciresi A. , Guarnotta V. , Perrone C. , Galluzzo A. , Giordano C.

Alterations in the thyroid axis have been reported following GH therapy both in adults and children with GH deficiency (GHD), even if the clinical significance of these changes, in small and short-term studies, remains uncertain. To evaluate the impact of GH replacement on thyroid status in a large selected cohort of prepubertal children with idiopathic GHD during a 3-years follow-up. Study outcome considered FT3, FT4 and TSH modifications (delta) during therapy and their corr...

ea0029p1516 | Pituitary Clinical | ICEECE2012

Visceral adiposity index is associated with insulin sensitivity and adipocytokine levels in newly diagnosed acromegalic patients

Ciresi A. , Amato M. , Guarnotta V. , Galluzzo A. , Giordano C.

Background: The Visceral Adiposity Index (VAI) has been suggested as a new gender-specific marker of visceral adipose dysfunction, strongly associated with insulin sensitivity in patients with cardio-metabolic risk.Aim: To test VAI in active acromegaly for the assessment of disease-associated metabolic risk evaluating its association with hormonal data, adipocytokine levels, insulin sensitivity and secretion parameters in a cohort of 27 subjects (15 M, 1...

ea0029p1782 | Thyroid cancer | ICEECE2012

Functional and molecular characterization of cancer stem cells in anaplastic thyroid carcinoma

Carina V. , Zito G. , Pizzolanti G. , Richiusa P. , Tomasello L. , Pitrone M. , Baiamonte C. , Guarnotta V. , Giordano C.

Anaplastic Thyroid Carcinoma (ATC) is the most aggressive thyroid gland malignancy characterized by undifferentiated morphology. It has been suggested that cancer stem cells (CSCs) might play a central role in ATC. Previously on the basis of CD133 positivity, our group suggested that CD133+ cancer stem cells (CSCs) might play a central role in ATC. Here we analyzed a panel of different stem cell markers in order to identify a peculiar CSC pattern in ATC....