Searchable abstracts of presentations at key conferences in endocrinology

ea0056p814 | Pituitary - Clinical | ECE2018

Pituitary enlargement due to the autoimmune thyroiditis mimicking a pituitary macroadenoma

Kiyici Sinem , Onlen Esen , Guclu Metin

Introduction: Pituitary tumorous hyperplasia with hyperprolactinemia has been described as a rare presentation of primary hypothyroidism. The loss of thyroxin feedback inhibition in primary hypothyroidism causes overproduction of thyrotropin-releasing-hormone (TRH), which results in secondary pituitary enlargement. TRH has a weak stimulatory effect on the lactotroph cells of the pituitary, so a mild to moderate increase in prolactin (PRL) levels is expected. This report descri...

ea0049gp112 | Diabetes therapy & complications 2 | ECE2017

Exenatide treatment causes suppression of serum fasting ghrelin levels in patients with type 2 diabetes Mellitus

Guclu Metin , Kiyici Sinem , Gul Zulfiye , Cavun Sinan

Aim: Ghrelin plays an important role in the stimulation of food intake and long-term regulation of body weight. In present study we investigate the long term effect of exenatide treatment on serum fasting ghrelin levels in patients with type 2 diabetes mellitus.Methods: Type 2 diabetic patients who were using metformin with and without the other oral antihiperglycemic drugs on a stable dose for at least 3 months were enrolled in the study. Body mass inde...

ea0063p306 | Reproductive Endocrinology 1 | ECE2019

A rare cause of the hypergonadotropic hypogonadism: GAPO sydrome

Guclu Metin , Gorukmez Ozlem , Gorukmez Orhan , Calışkan Yasemin , Kiyici Sinem , Kisakol Gurcan

GAPO syndrome (OMIM 230740) is a rare, multiple congenital anomalies syndrome characterized by Growth retardation, Alopecia, Pseudoanodontia and Ocular manifestations. Syndrome caused by anthrax toxin receptor 1 (ANTXR1) gene (NM_032208.2) mutation leading to deficiency of an enzyme involved in the metabolism and breakdown of extracellular matrix (ECM). Disease show parental consanguinity, autosomal recessive inheritance and since first description in 1947 a total of 38 patien...

ea0063p616 | Diabetes, Obesity and Metabolism 2 | ECE2019

Serum total and bioactive fibroblast growth factor 21 levels are similar in patients with gestational diabetes mellitus and healthy pregnant controls

Celik Ali Osman , Kiyici Sinem , Ustundag Yasemin , Sigirli Deniz , Guclu Metin , Ustunyurt Emin

Aim: Fibroblast growth factor (FGF) 21 is a hormone which plays an important role in metabolic diseases such as diabetes, obesity and dyslipidemia. In this study; we aimed to investigate the serum total and bioactive FGF21 levels in patients with gestational diabetes mellitus (GDM) and compared with healthy pregnant controls.Material and Methods: A two-step screening method and Carpenter and Coustan criteria were used in the diagnosis of...

ea0037ep452 | Diabetes (complications & therapy) | ECE2015

The effect of exenatide treatment on serum ghrelin levels in patients with type 2 diabetes

Topyildiz Figen , Kiyici Sinem , Gul Zulfiye , Sigirli Deniz , Guclu Metin , Kisakol Gurcan , Cavun Sinan

Aim: Ghrelin plays an important role in stimulation of food intake and long-term regulation of body weight. In present study we aimed to investigate the effect of exenatide treatment on serum ghrelin levels in patients with type 2 diabetes.Methods: Fourteen women patients with type 2 diabetes treated with metformin and exenatide were enrolled in the study. A mixed meal test was applied to the patients while they were using their daily medications. Serum ...

ea0037ep1062 | Thyroid (non-cancer) | ECE2015

Serum prolactin and macroprolactin levels in pregnancy and association with thyroid dysfunction and thyroid autoimmunity

Guclu Metin , Cander Soner , Kiyici Sinem , Vatansever Ebru , Hacihasanoglu Arif Bayram , Kisakol Gurcan

Aim: To assess the contribution of macroprolactin (macroPRL) to high serum prolactin (PRL) levels and association of prolactin and macroprolactin levels with thyroid status and thyroid autoimmunity during pregnancy.Methods: Pregnant women (n=138) who had undergone a thyroid-stimulating hormone (TSH) screening during the first trimester of pregnancy enrolled in the study. Serum prolactin, macroprolactin, TSH, FT4, FT3, and thyroid autoantibodies ...

ea0020p46 | Adrenal | ECE2009

Insulin hypoglycemia test in the diagnosis of subclinical Cushing’s syndrome

Yener Ozturk Feyza , Erturk Erdinc , Guclu Metin , Kiyici Sinem , Unal Oguzkaan , Imamoglu Sazi

Although subclinical Cushing’s syndrome (SCS) is an important metabolic risk factor in patients with adrenal incidentaloma, the diagnostic criteria for SCS has not been established yet. The aim of this study was to evaluate the diagnostic measures of SCS and to investigate the availability of insülin hypoglycemia test (IHT) in the diagnosis of SCS. Twenty patients with adrenal incidentaloma CT characteristics highly suggestive of benign adrenal adenoma with no overt ...

ea0020p85 | Thyroid | ECE2009

Is there any beneficial effect of L-thyroxine replacement theraphy on cardiovascular risk factors in patients with subclinical hypothyroidism?

Unal Oguz Kaan , Erturk Erdinc , Sarandol Emre , Eroz Esma , Kiyici Sinem , Guclu Metin , Imamoglu Sazi

The relationship between increased risk of cardiovascular disease (CVD) and atherosclerosis in subclinical hypothyroidism (sHT) have been demonstrated in several studies. This relation was attributed to dyslipidemia which is common in sHT. Apo A1, apo B100, Lp (a), hsC-reactive protein (hsCRP), fibrinogen and total homocysteinemia (tHcy) are the main non-traditional cardiovascular risk factors. In addition, paraoxon 1 (PON 1) activity is an enzyme responsible for the anti-oxid...

ea0020p433 | Diabetes and Cardiovascular | ECE2009

The effect of telmisartan and irbesartan treatments on insulin resistance of patients with type 2 diabetes and hypertension

Tasli Babursah , Oz Gul Ozen , Tuncel Ercan , Guclu Metin , Kiyici Sinem , Imamoglu Sazi

Hyperinsulinemia that occurs due to insulin resistance play an important role on the development of type 2 diabetes and hypertension. It is shown that apart from their angiotensin II receptor blockage effect, telmisartan and irbesartan can activate intracellular hormone receptor PPARγ. Owing to this dual effect, telmisartan and irbesartan can improve cardiovascular risk factors related to insulin resistance. The aim of this study was to compare the effects of telmisartan ...

ea0056p557 | Obesity | ECE2018

Effect of surgical weight loss on the inflammatory hematological parameters in short term

Nemli Hilal , Kisakol Gurcan , Devrim Kucuksarac Kiyici Sinem , Guclu Metin , Koca Nizameddin

Introduction: In obesity, MPV is found higher compared to healthy controls. It was found that the level of NLR was predictive of the development of type 2 diabetes with high sensitivity and specificity in morbid obese patients. PLR is a new biological indicator that can assess the presence and severity of inflammation. However, in obese patients PLR was not found to associate with degree of of obesity or ratio of weight loss. Regarding the platelet count (PC) in obesity, confl...