Endocrine Abstracts

Introduction: People living with human immunodeficiency virus (HIV) are at increased risk of developing metabolic disorders, such as obesity, dyslipidemia, insulin resistance, diabetes and hypertension; which may also be associated with hypercortisolism. Due to the similarity between the metabolic changes present in these two clinical situations, several studies have evaluated whether HIV-infected patients have increased levels of cortisol, but the results are not consensual. ...

Introduction: Lipodystrophies are a group of genetic or acquired diseases characterized by abnormal adipose tissue deposition, frequently associated with insulin resistance, diabetes mellitus, dyslipidaemia, hypertension and hepatic steatosis. Congenital generalized lipodystrophy (LCG) is a well-defined syndrome with autosomal recessive heredity, prevalence <1:10million, with about 400 cases being described. Extreme shortage of subcutaneous adipose tissue, muscle hypertrop...

Introduction: Adipose tissue disturbances (lipodystrophy and obesity) are prevalent in patients infected with HIV. Our aims were to evaluate the prevalence of obesity and the association with lipodystrophy, the effect of gender, age, viral replication, duration of disease and cART in a population of HIV patients under cART.Methods: In this retrospective study, 580 patients were included. The characteristics of the population are presented through percent...

Introduction: Plasma glucose concentration at 1h(1hPG) during an oral glucose tolerance test(OGTT) may be a better predictor of future diabetes mellitus(DM) than 2-h post load glucose concentration(2hPG). HIV-infected individuals may have differential risk of DM compared to the general population, and the optimal diagnosis algorithm for DM in HIV-infected persons remain unclear. We evaluated the agreement of the methods 1 hPG vs 2 hPG) for the diagnosis of pre-D...

Introduction: Medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) are two distinct neoplasms originating from follicular and parafolicular-C cells, respectively. These pathologies have always been considered different from each other in terms of their incidence, their cell origin and their histopathological features. Concurrent occurrence of MTC and PTC in the same patient is an unusual event and its occurrence as true mixed medullary-follicular-derived car...

Neuroendocrine neoplasms (NENs) arise from specialized cells called neuroendocrine cells spread through the body, mainly in the gastrointestinal tract, pancreas and lung. Pathological classification of Lung NENs include well differentiated NENs, that can be classified as typical or atypical carcinoids, and poorly differentiated neuroendocrine carcinomas (NECs), classified as small-cell lung carcinoma (SC-NEC) or large-cell neuroendocrine carcinoma (LC-NEC). We present a case o...

Introduction: Magnesium (Mg) is an essential mineral for human health. Chronic Mg2+ deficiency and low Mg2+ dietary intake have been associated with increased risk of T2DM. Despite the increased risk of T2DM associated with Mg2+ deficiency; T2DM is often accompanied by hypomagnesemia, especially in patients with poorly controlled glycemic profiles.Bariatric surgery remains the most effective long-term therapy for the management of patients wi...

Introduction: Despite the abundance of data addressing the influence of patient’s age on surgery-related complications, its impact on several cardiovascular risk factors following bariatric surgery has been overlooked.Methods: Retrospective unicentric study of 1728 obese patients who underwent bariatric surgery between January/2010 and June/2015. Patients were divided in three groups, according to their age at surgery: <40 (n = 751...

Background: Bariatric surgery leads to weight loss and to cardiometabolic risk improvement. Although prediabetes remission after bariatric surgery is biologically plausible, data on this topic is scarce.Aim: We aimed to access pre-diabetes remission rate and clinical predictors of remission in a 4 year follow up period.Methods: Observational longitudinal study including patients with morbid obesity and prediabetes submitted to bari...