Searchable abstracts of presentations at key conferences in endocrinology

ea0073oc13.1 | Oral Communications 13: Pituitary and Neuroendocrinology | ECE2021

TP53 mutations in functional corticotroph tumours: prevalence and clinical relevance

Perez-Rivas Luis Gustavo , Simon Julia , Albani Adriana , Rotermund Roman , Hermus Perez-Rivas , Guillaume Assié , Gadelha Monica , Deutschbein Timo , Flitsch Jörg , Honegger Jürgen , Rachinger Walter , Stalla Günter , Reincke Martin , Theodoropoulou Marily

IntroductionTP53 mutations have been rarely reported in pituitary tumours. Recently two exploratory exome sequencing studies have identified somatic TP53 mutations in a small number of functional corticotroph tumours (6/18 and 4/10) with USP8 wild type (wt) status, suggesting that they may be more frequent than previously thought. Nevertheless, the clinical impact of those mutations is still unknown.AimTo det...