Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep810 | Pituitary: clinical | ECE2015

Pasireotide long-acting release maintains biochemical control in patients with acromegaly: results from the extension of randomised, Phase III, PAOLA study

Colao Anna Maria , Bronstein Marcello D , Brue Thierry , Coculescu Mihail , Marinis Laura De , Fleseriu Maria , Guitelman Mirtha A , Pronin Vyacheslav , Raverot Gerald , Shimon Ilan , Fleck Juergen , Kandra Albert , Pedroncelli Alberto M , Gadelha Monica R

Introduction: The PAOLA study in patients with inadequately-controlled acromegaly (n=198) demonstrated superior efficacy of pasireotide long-acting release (LAR; 40 mg/60 mg) in biochemical control (GH <2.5 μg/l and normalized IGF-1) vs continued treatment with octreotide LAR 30 mg/lanreotide Autogel 120 mg (15.4% and 20.0% vs 0%). Here we report preliminary data from the extension phase of PAOLA at wk28.Methods: Pasireotide-LAR (40 mg/...

ea0035p907 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Pasireotide LAR demonstrates superior efficacy versus octreotide LAR and lanreotide ATG in patients with inadequately controlled acromegaly: results from a phase III, multicentre, randomized study (PAOLA)

Gadelha Monica , Bronstein Marcello , Brue Thierry , Coculescu Mihail , Fleseriu Maria , Guitelman Mirtha , Pronin Vyacheslav , Raverot Gerald , Shimon Ilan , Lievre Kayo Kodama , Fleck Juergen , Aout Mounir , Pedroncelli Alberto , Colao Annamaria

Background: Some patients with acromegaly do not achieve biochemical control despite receiving maximum-approved doses of currently available somatostatin analogues. This 24-week, randomized study assessed the multireceptor-targeted somatostatin analogue pasireotide LAR vs octreotide LAR/lanreotide Autogel in patients with inadequately controlled acromegaly.Methods: Eligible patients: ≥18 years with mean GH levels ≥2.5 μg/l and IGF1 level...

ea0014p550 | (1) | ECE2007

OASIS: observational study on the international clinical practice for the treatment of recently diagnosed acromegalic patients

Portocarrero Lesly , Akçay Güngör , Bouterfa Hakim , Carvalho Davide , Greenman Yona , Gu Feng , Guitelman Mirtha A , Kim Sungwoon , Kriesche Christine , Mercado Moises , Shen Chiung-Chi , Silva Antonio , Varela Cesar , Wallaschofski Henri , Webb Susan

Background: There is significant interest in how the use of different treatment regimens (e.g. surgery, medical therapy) impacts the clinical course of Acromegaly. This study has been designed to better understand clinical decision making in the context of various treatment options.Methods: OASIS is an international, observational study in recently diagnosed acromegalic patients. Ethical committee approval was obtained where applicable. Observations incl...

ea0090ep799 | Pituitary and Neuroendocrinology | ECE2023

Craniopharyngiomas in adult patients: Retrospective, multicentric study in Buenos Aires, Argentina

Mallea-Gil Susana , Glerean Mariela , Rogozinski Amelia , Ballarino Carolina , Battistone Maria Florencia , Danilowicz Karina , Diez Sabrina , Day Patricia Fainstein , Furioso Alejandra , Guitelman Mirtha , Katz Debora , Loto Monica , Martinez Marcela , Miragaya Karina , Sosa Soledad , Slavinsky Patricia , Tkatch Julieta , Vitale Marcelo , Pernas Valeria Gonzalez , Roel Valeria Garcia , Pingel Jesica

Craniopharyngiomas are rare lesions derived from cell remnants of Rathke’s pouch, usually localized in the sellar and suprasellar areas.Objectives: To analyze clinical, endocrine and histological features in a group of patients from Buenos Aires city. To assess efficacy, number of surgeries and complications after surgery or other treatments.Material and methods: Multicentric, retrospective, transversal study. Adult patients w...