Endocrine Abstracts

Primary hyperparathyroidism (PHPT) is the third common disorder of the endocrine system. It reaches a peak incidence between ages 50–60. Biochemical screening has increased its incidence up to one per 1000 (USA), and most cases are presented with asymptomatic mild hypercalcemia. The most common cause in affected individuals is a functioning single parathyroid adenoma. In advanced cases, bones (brown tumours, osteitis fibrosa cystica) and the kidney (nephrolithiasis, nephr...

Background: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a newly described indolent thyroid tumor with well-defined histopathological diagnostic criteria. Even though the histopathologic features and diagnostic criteria for NIFTP are well-established, preoperative diagnosis using sonographic or fine needle aspiration findings has yet to be confirmed. The aim of this study is to compare the clinical, sonographic, and cytological charac...

Introduction: No consensus guideline on the treatment of hypoparathyroidism. Hypoparathyroidism is a disease characterized by hypocalcaemia and insufficient PTH. Conventional therapy includes calcium and active vitamin D supplementation, often in large doses.Case report: A 31-year-old woman presented with hypercalcemia. Serum calcium and phosphorus levels were 10.5 and 2.56 mg/dl respectively. The serum PTH level was increased (1619 pg/ml). The serum 25-...

Background and Aim: Prevalence of Hashimoto’s thyroiditis is increasing in Turkey. GH deficiency has been reported to associate with this disorder in several different ethnic population. The aim of this study was to evaluate GH deficiency in the population with Hashimoto’s thyroiditis.Materials and methods: Euthyroid Hashimoto’s thyroiditis patients, who admitted to the Department of Endocrinology and Metabolism of Hacettepe University, we...

Background and Aim: Prolactinoma is the most common type of functional pituitary tumor in adults. Giant prolactinomas are defined as tumors achieve a diameter >4 cm and often have very high serum prolactin level. In our previous study showed that endoscopic endonasal pituitary surgery is a very convenient procedure for the patient due to low morbidity and high efficiency. In this study we evaluated endoscopic endonasal pituitary surgery series in patients with prolactinoma...

Background and aims: The type 1 DM patients who are GAD antibody positive have more risk of autoimmune thyroid disease than who are negative. In patients with autoimmune thyroid disease there is a significantly increased risk of anti-pancreatic autoimmune response as shown by increased GAD antibody positivity compared to normal population. However, the linkage between IA2 and thyroid autoimmunity is evaluated in one studied. Our aim is to evaluate the frequency of presence of ...

Background: Various molecular mechanisms play a role in the pathogenesis of papillary thyroid cancer(PTC). Understanding the underlying pathogenesis and genetic changes is needed to improve clinical outcomes in PTC. In this study, it was aimed to determine the frequency of, BRAF V600E TERT promoter and NRAS mutations in Turkish patients with papillary thyroid cancer, the relationship of mutations between clinicopathological features and distant met...

Background: Immune function and responses are tightly regulated by the circadian clock system and hypothalamic-pituitary-adrenal (HPA) axis. Accumulating evidence supports that there is a strong mutual relationship between these two regulatory systems at multiple levels. Recent publications suggest that the clock system may also regulate glucocorticoid release from adrenal glands by altering the sensitivity of the adrenal cortex to adrenocorticotropic hormone (ACTH).<p cla...

Background: Circadian rhythmicity is generated by a set of genes including Period3. Changes in the expression of Period3 and other clock genes have been linked with regulation of the immune system. Period3 polymorphisms have been associated with circadian disruption and so immune system dysregulation and altered secretion of several cytokines, which can lead to inflammatory and autoimmune disorders.Aim: To investigate the influence of a polymorphism in P...

Background and aim: Incidentally discovered adrenal masses (adrenal incidentalomas (AI)), generally 1 cm or more in diameter, are mostly benign and asymptomatic and are often considered as nonfunctional tumors. The aim of this study was to perform the imaging characteristics, endocrinologic screening and histologic diagnoses of adrenal incidentaloma cases encountered in our institute.Methods: This retrospective evaluation of patients with AI includes 543...