Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep606 | Endocrine tumours and neoplasia | ECE2016

Novel mutations p.V220E and c.30G>T in menin gene are associated with hereditary predisposition to multiple endocrine neoplasia type 1

Ziemnicka Katarzyna , Budny Bartlomiej , Gut Pawel , Hernik Aleksandra , Leitgeber-Dominiczak Olena , Siudzinski Marcin , Gryczynska Maria , Janicki Adam , Ruchala Marek

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant condition characterized by varying combinations of endocrine tumors and commonly accompanying hyperplasia within the parathyroid gland, anterior pituitary and gastrointestinal tract. Heterozygous germline mutation of the tumor suppressor gene MEN1 is the most common cause of the disease. Molecular genetic testing of menin gene, in which mutation is known to cause MEN1 syndrome, detects pathogenic...

ea0020p325 | Clinical case reports and clinical reports | ECE2009

Malignant struma ovarii: a case report

Gryczynska Maria , Matysiak-Grzes Magdalena , Klimowicz Aleksandra , Czepczynski Rafal , Gut Pawel , Wachowiak-Ochmanska Katarzyna , Nowakowski Blazej , Sowinski Jerzy

Background: Struma ovarii is a rare form of the ovarian germ cell tumors composed predominantly of mature thyroid tissue. It occurs mostly in the fifth decade. About 5–10% of these tumors are malignant. We present the case of a 20-year-old-woman with papillary thyroid carcinoma arising in struma ovarii.Case report: A 20-year-old woman presented to her gynecologist with pelvic pain. A right ovarian tumor was discovered at ultrasound examination. The ...

ea0037ep956 | Thyroid (non-cancer) | ECE2015

The role of antithyroglobulin, antiperoxidase and anti-TSH autoantibodies in amiodarone induced thyrotoxicosis or amiodarone induced hypothyroidism (a two-center study)

Czarnywojtek Agata , Zgorzalewicz-Stachowiak Malgorzata , Fichna Marta , Wolinski Kosma , Plazinska Maria Teresa , Stangierski Adam , Gut Pawel , Miechowicz Izabela , Komarowska Hanna , Czepczynski Rafal , Krolicki Leszek , Ruchala Marek

Purpose: In the recent study it has been reported, that elevated serum concentrations of TSH receptor (TSH-R), antithyroglobulin (Tg), antiperoxidase (TPO) autoantbodies (Abs) may be observed in the subjects treated for amiodarone induced thyrotixicosis (AIT) type I, decreased in type II of AIT, or changed in amiodarone induced hypothyroidism (AIH). This study was done to analyse the changes of Tg-Abs, TPO-Abs and TSH-R-Abs titer in euthyroid, hyperthyroid (AIT), and hypothyro...

ea0035p1035 | Thyroid (non-cancer) | ECE2014

Results of preventive radioiodine therapy in euthyroid patients with history of hyperthyroidism prior to administration of amiodarone with permanent atrial fibrillation (preliminary study)

Czarnywojtek Agata , Wolinski Kosma , Gut Pawel , Czepczynski Rafal , Plazinska Maria Teresa , Kunikowska Jolanta , Kobylecka Malgorzata , Miechowicz Izabela , Krolicki Leszek , Ruchala Marek

Introduction: Radioiodine (RAI) therapy is a standard procedure in therapy of hyperthyroidism. However, the use of RAI in euthyroid patients requiring chronic administration of amiodarone (AM), in a case of lacking efficacy of other antiarrhythmic drugs might be controversial.Objective: The aim of the study was to assess the safety and efficacy of an AM therapy prior to treatment with radioiodine therapy in euthyroid patients with permanent atrial fibril...