Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc6.5 | Cardiovascular endocrinology | ECE2007

Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression in mononuclear blood cells: a randomized trial in healthy men

Gouni-Berthold Ioanna , Berthold Heiner , Gylling Helena , Ko Yon , Plat Jogchum , Krone Wilhelm

Context: Ezetimibe and simvastatin are often used in combination to lower blood lipid levels. The consequences of this combination at the molecular level are unknown.Objective: To examine their effects on the LDL receptor (LDLR) protein expression and on the LDLR and HMG-CoA reductase gene expression in peripheral blood mononuclear cells (PBMC).Design, setting and participants: Prospective, randomized, parallel 3-group trial. Twent...

ea0022p258 | Developmental endocrinology | ECE2010

De novo cholesterol synthesis in developing mouse embryo is required for embryonic survival

Jokela Heli , Rantakari Pia , Lamminen Tarja , Strauss Leena , Ola Roxana , Gylling Helena , Miettinen Tatu , Pakarinen Pirjo , Sainio Kirsi , Poutanen Matti

Hydroxysteroid (17-β) dehydrogenase enzymes (HSD17Bs) have an important role in sex steroid hormone metabolism. They are known to catalyze reactions between highly active 17β-hydroxy steroids and less active 17-keto steroids. In addition to sex steroid metabolism, it is becoming evident that HSD17Bs have functions in other pathways as well, e.g. lipid and bile acid metabolism. HSD17B type 7 enzyme is known to catalyze in vitro the activation of estrone (E1) to...