Searchable abstracts of presentations at key conferences in endocrinology

ea0016p88 | Bone and calcium | ECE2008

R-568 improves transmembrane signal transduction of inactivating mutations of the calcium-sensing receptor

Rus Ramona , Haag C , Schulze E , Frank-Raue K , Raue F , Schofl Christof

Inactivating mutations of the calcium-sensing receptor (CaSR) gene, present in homozygous or heterozygous forms, cause neonatal severe hyperparathyroidism or familial hypocalciuric hypercalcemia. The R-568 binds to the transmembrane region of the CaSR thereby enhancing its sensitivity to extracellular calcium ([Ca2+]o) and inhibiting parathyroid hormone (PTH) secretion. The therapeutic potential of calcimimetics like R-568 has been demonstrated in patient...