Endocrine Abstracts

Sertoli Cell Only Syndrome (SCOS) is a rare cause of male infertility in which the cause is often unknown. Here, we report an unusual presentation of SCOS in a 32 year old man with severe fatigue, flushing, aches and hypothyroidism. These symptoms did not improve despite correcting hypothyroidism with thyroxine replacement. There have been no features of depression and he has been investigated thoroughly as predominant fatigue has been...

Sertoli Cell Only Syndrome (SCOS) is a rare cause of male infertility in which the cause is often unknown. Here, we report an unusual presentation of SCOS in a 32 year old man with severe fatigue, flushing, aches and hypothyroidism. These symptoms did not improve despite correcting hypothyroidism with thyroxine replacement. There have been no features of depression and he has been investigated thoroughly as predominant fatigue has been...

Hypothyroidism is a common endocrine condition and if untreated can have serious consequences in pregnant women. Generally, TSH receptor antibodies (TRAb) is performed in hyperthyroid pregnant women as high titres can cause foetal hyperthyroidism Neonatal thyrotoxicosis develops in 1% of infants born to thyrotoxic mothers due to placental transfer of TRAb.As part of management of hypothyroid pregnant women, TRAb are checked routinely in our hospital in k...

Introduction: A 77-year-old man with glipizide treated type 2 diabetes presented acutely unwell, with weakness, intermittent breathlessness, and poor glycaemic control (previously well control with HBA1c of 42 mmol/mol). Initial assessment showed body weight of 74.5 kg, mild leg oedema, blood pressure of 190/100 mmHg, expiratory wheeze, oxygen saturation 91% and PO2 7.8 mmHg on air. Chest XR showed chronic right lower lobe shadowing and a bulky hilum. His plasma glu...

Adrenal haemorrhage is rarely associated with anticoagulation according to a large American series. We present 2 cases in whom there was no evidence of over anticoagulation, both of whom developed a degree of hypoadrenalism.Case 1: A 72-year-old-male presented with severe non-pleuritic left flank pain. He had been seen the previous day with possible deep venous thrombosis (DVT) and had received a single dose of enoxaparin (1.5 mg/kg). He was tender in th...

Thyroid nodules are common, but the incidence of thyroid cancer occurring within them is very low. Nonetheless, patients presenting with thyroid lumps are frequently worried that they have cancer, and the wait for a diagnosis to be confirmed or refuted is highly stressful. This presents challenges to the clinician, in determining who requires extensive investigations, and how best to reassure patients in whom this is not indicated. However, satisfied patients are more likely t...

Background: Early diagnosis of thyroid cancer has a significant impact on outcome. However, the identification of incidental microcarcinomas potentially leads to raised anxiety and overtreatment in some cases. Ultrasound (US) guided FNA is therefore the initial investigation of choice, and NICE recommends that patients presenting clinically with a thyroid lump or swelling should be seen by a specialist within two weeks of the referral. We launched a multidisciplinary thyroid l...

Hypoadrenalism and bilateral adrenal haemorrhage are rare manifestations of lymphoma. We present a case of diffuse large B cell non-Hodgkins lymphoma (NHL) in whom the main manifestations of relapse included hypoadrenalism and then bilateral adrenal haemorrhage.A 75-year-old male presented with a 2-week history of severe left sided abdominal pain. He was known to have NHL predominantly involving the right maxillary sinus, which had been treated with chem...