Searchable abstracts of presentations at key conferences in endocrinology

ea0014p529 | (1) | ECE2007

Non-NMDA glutamate receptor antagonist injected into the mesencephalic dorsal raphe nucleus inhibits the suckling-induced prolactin release and administered into the lateral cerebral ventricle interferes with the diurnal fluctuations of plasma prolactin of male rats

Bodnár Ibolya , Bánky Zsuzsanna , Halász Béla

We examined the functional significance of the glutamatergic innervation of the dorsal raphe nucleus (DR) in the mediation of the suckling stimulus inducing prolactin release. A non-NMDA (6-cyano-7-nitroquinoxaline-2,3-dione disodium, CNQX) or an NMDA glutamate receptor antagonist (dizocilpine hydrogen malate, MK-801) was injected into the DR of freely moving lactating rats at the end of 4 h separation. The litters were then returned and blood samples for prolactin were taken ...

ea0014p525 | (1) | ECE2007

Glutamatergic neurons and synaptic contacts between glutamatergic axon terminals and chemically identified nerve cells in the rat hypothalamic suprachiasmatic nucleus

Kiss József , Csaba Zsolt , Csáki Ágnes , Halász Béla

The hypothalamic suprachiasmatic nucleus (SCN) is the key-structure of the control of circadian rhythms. Several observations support the view that glutamate is the primary transmitter of the retinal projection to this cell group. The glutamatergic innervation of the nucleus is not limited to this projection, it is much more extended. The aim of our investigations was (1) to examine whether are glutamatergic neurons existing in the SCN and (2) to get information about the rela...

ea0014p484 | (1) | ECE2007

Severe hyperandrogenism during the entire course of pregnancy does not cause virilization of a female infant born

Bertalan Rita , Halász Zita , Csabay László , Rigó János , Németh Sándor , Blázovics Anna , Toke Judit , Boyle Belema , Rácz Károly

Objevtives: Maternal hyperandrogenism occurs rarely during pregnancy as the consequense of maternal ovarian or adrenal disorders, or placental aromatase deficiency.Case: A 33-year-old pregnant women was referred because of high serum testosterone (240 ng/dl; normal, 20–60 ng/dl) measured at the 7th week of pregnancy. At presentation she had symptoms of moderate hyperandrogenism, which slightly increased until delivery. Abdominal and pelvic ultrasoun...

ea0014p585 | (1) | ECE2007

Genetic analysis of PROP1 gene in patients with childhood-onset combined pituitary hormone deficiency (CPHD)

Halász Zita , Toke Judit , Patócs Attila , Bertalan Rita , Tömböl Zsófia , Sallai Ágnes , Hosszú Éva , Muzsnai Ágota , Kovács László , Sólyom János , Fekete György , Rácz Károly

Introduction: Combined pituitary hormone deficiency (CPHD) may be associated with mutations of genes coding for pituitary transcription factors, of which the PROP1 and Pit1, gene mutations have been most extensively studied. However, there are controversial data about the prevalence of these gene mutations in non-acquired childhood-onset CPHD patients.Objectives: To examine the prevalence and spectrum of PROP1 and Pit1 gene mutations in CPHD patients a m...