Endocrine Abstracts

Background: Cushing’s disease is the most common cause of endogenous Cushing’s syndrome in adults, affecting females>males (ratio 3:1). In suspected cases, careful clinical assessment is required to ascertain a pre-test probability. This is followed by robust biochemical testing, which guides further management.One-week test protocol: Congruent biochemical tests are conducted over a one-week period in an outpatient setting. Patients attend on d...

Introduction: Hyponatraemia is the commonest electrolyte disturbance, but is not common in young people. Here, we describe a female subject, with recurrent unexplained symptomatic hyponatraemia in whom we considered the possibility of an activating mutation in the arginine vasopressin receptor type 2 (AVPR2) as a rare cause of Syndrome of Inappropriate Anti-Diuresis (SIAD).Case: A 39 year old woman had a history of unexplained hyponatraemia (serum sodium...

Introduction: Hyponatraemia is the commonest electrolyte disturbance, but is not common in young people. Here, we describe a female subject, with recurrent unexplained symptomatic hyponatraemia in whom we considered the possibility of an activating mutation in the arginine vasopressin receptor type 2 (AVPR2) as a rare cause of Syndrome of Inappropriate Anti-Diuresis (SIAD).Case: A 39 year old woman had a history of unexplained hyponatraemia (serum sodium...