Endocrine Abstracts

Introduction: The effects of finasteride on insulin resistance and of metformin on hyperandrogenism in patients with polycystic ovary syndrome (PCOS) are not clear. This study therefore compared the effects of finasteride, metformin, and finasteride plus metformin treatments on hormone levels, insulin resistance, and hirsutism score in women with PCOS.Subjects and method: Fifty-two patients with PCOS were randomly assigned to receive finasteride 5 mg/day...

Objective: Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is a very rare congenital anomaly characterised by vaginal agenesis and a spectrum of different genitourinary tract anomalies. Typical form of this syndrome is characterised by congenital absence of the uterus and upper 2/3 vagina with normal ovaries and fallopian tubes and atypical form of the syndrome is associated with anomalies of the ovaries and fallopian tubes and renal anomalies.Case r...

A 37-year-old patient with a history of transcranial pituitary surgery because of acromegaly was referred to our clinic with the glucose level 731 mg/dl. she was not using any medication. There was no ketone in the urine and HbA1c was 18.6%. She has 17×16×15 mm of residual macroadenoma on pıtuıtary MRI with level of GH 17.5 ng/ml and IGF-1 422 ng/ml. She was using 140 units of insulin glargin U300 and 100 units of insulin regular per a day before octreotide...

Introduction: Although, vitamin D (vit D) mainly regulates calcium and phosphate metabolisms, its deficiency may also contribute to the development of some carcinomas, autoimmune, and cardiac diseases. Vit D deficiency has been defined to correlate with increased autoimmune disease such as type 1 diabetes mellitus, rheumatoid arthritis, autoimmune thyroid diseases (AITD). Previous studies suggested that patients with AITD had lower vit D levels when compared with healthy contr...

Introduction: Traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), stroke and cerebrovascular disease (CVD) are identified as risk factors for hypopituitarism. However, the mechanisms and the risk factors for the hypothalamo-pituitary dysfunction due to TBI, SAH, stroke and CVD are still unclear (1,2,3). Hypoxia, hypoxemia, neuroinflammation, autoimmunity could have impact in the pathogenesis (4). In patients with serious ventricular arrhythmias who need resuscitation,...