Endocrine Abstracts

PGC1 and RIP140 are key regulators of nuclear receptor signalling that control metabolic gene expression in adipose tissue, liver and muscle. PGC1 promotes whereas RIP140 represses the expression of a network of catabolic genes in adipose and muscle. Thus mice devoid of RIP140 accumulate less fat in adipose tissue and liver while mitochondrial biogenesis and respiration is increased in type 2 muscle fibres; as a consequence, the mice maintain their insulin sensitivity as they ...