Searchable abstracts of presentations at key conferences in endocrinology

ea0089c30 | Clinical – Surgery/Applied Pathology | NANETS2022

Liver-Directed Therapy of Neuroendocrine Liver Metastases

Meloche-Dumas Leamarie , Mercier Frederic , Barabash Victoria , Law Calvin , Coburn Natalie , Singh Simron , Myrehaug Sten , Chan Wing , Hallet Julie

Background: The optimal therapy sequencing for metastatic neuroendocrine tumors (NETs) remains undefined. Recent advances in systemic therapies may have changed approaches. Better understanding in patterns of care is necessary to assess and design treatment strategies. We examined the use of factors associated with liver-directed therapy over time.Methods: We conducted a population-based study of metastatic NETs over 2000-2019. Outcomes were use of liver...

ea0098b20 | Basic Science | NANETS2023

Establishment of novel PDXovo models for gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs)

Kulathunga Nilakshi , Mar Sara , Wang Zoey , Qureshi Areeba , Tsui Hubert , Hallet Julie , Law Calvin , Leong Hon S. , Michael Iacovos P.

Background: Neuroendocrine cancers arise in the endocrine cells localized throughout the body. Most are found in the Gastroenteropancreatic (GEP) system pancreas, stomach, and small and large intestines. They are heterogenous in their etiology, morphology, and phenotypes. Due to late diagnosis and low prevalence, clinical specimens are limited for research. Thus, preclinical models are pivotal for the understanding of this disease. This study focuses on establishing a novel pa...

ea0098c49 | Clinical – Surgery/Applied Pathology | NANETS2023

Post-procedure outcomes of liver-directed therapy of neuroendocrine liver metastases

Meloche-Dumas Leamarie , Mercier Frederic , Barabash Victoria , Law Calvin , Singh Simron , Myrehaug Sten , Chan Wing , Hallet Julie

Background: While there have been major advances in the care of neuroendocrine tumors (NETs), there is still no widely adopted therapeutic sequencing in metastatic NETs. The roles and benefits of locoregional treatments need reassessment, in order to define a modern therapeutic algorithm. We examined contemporary short-term outcomes of liver-directed therapy for metastatic NETs.Methods: We conducted a population-based retrospective cohort study of patien...

ea0098c57 | Clinical – Surgery/Applied Pathology | NANETS2023

Perioperative management of carcinoid crisis: protocol for a modified Delphi international expert consensus statement with patient engagement

Hallet Julie , Alam Fahad , Rocha Flavio , Del Rivero Jaydira , Partelli Stefano , Koea Jonathan , Ladowski Stephanie , Saliba Chadi , Pommier Rodney

Background: Patients with neuroendocrine tumors (NETs) are at risk of carcinoid crisis when undergoing operations, which is associated with adverse post-operative outcomes. There is no contemporary guideline regarding the perioperative management of patients at risk of carcinoid crisis. Moreover, recent evidence has challenged traditional management with somatostatin analogs preparation and avoidance of beta-adrenergic medication. Therefore, specific guidance is needed to prov...

ea0098p9 | Population Science | NANETS2023

Contemporary incidence and survival of lung neuroendocrine neoplasms: a population-based study

Rousseau Mathieu , Wakeam Elliott , Singh Simron , Myrehaug Sten , Law Calvin , Barabash Victoria , C Chan Wing , Hallet Julie

Background: While the epidemiology of overall and gastrointestinal neuroendocrine neoplasms (NENs) has been reported, data specific to lung NENs remain scarce. Such understanding is crucial in designing tailored strategies to improve care and outcomes. We examined the incidence, overall survival (OS), and disease-specific death (DS-deaths) for lung NENs.Methods: We conducted a population-based retrospective cohort study of adult patients with incident lu...

ea0098b3 | Basic Science | NANETS2023

Translational biomarkers in G2-3 NENs: Analysis from NET-001 and NET-002 trials

Nunez Jose E. , Bruce Jeffrey , Danesh Arnavaz , Chan David L. , Rodriguez-Freixinos Victor , Hallet Julie , Myrehaug Sten , Law Calvin , Pugh Trevor , Singh Simron

Background: The treatment of neuroendocrine neoplasms (NENs) of higher grade remains a dilemma. In these patients the role of immunotherapy is still unclear and predictive biomarkers are an unmet need. Herein, we present a revised translational analysis of the NET001 and NET002 (NCT03278405, NCT03278379) clinical trials.Methods: Patients with advanced WHO G2-3 NENs who had a gastroenteropancreatic (GEP) or a bronchial primary (excluding typical carcinoid...

ea0089p4 | Population Science | NANETS2022

Carcinoid Heart Disease in Patients Diagnosed with Small Bowel and Lung Neuroendocrine Tumors

MD, MSc Julie Hallet , MD, MPH Katrina Duncan , MD, MPH Simron Singh , MSc Victoria Barabash , MD Shaheeda Ahmed , MD Sten Myrehaug , MD, MPH Natalie Coburn , MD, MPH Calvin Law

Background: Carcinoid heart disease (CHD) is a complication of neuroendocrine tumors (NETs). While its pathophysiology and manifestations are described, little is known about its occurrence in all patients diagnosed with NETs. We examined the occurrence of CHD and explored the use of echocardiography after diagnosis of NET.Methods: We conducted a population-based retrospective cohort study of adults diagnosed with small bowel and lung NETs (2000-2019). C...