Endocrine Abstracts

Introduction: In acromegaly GH excess leads to impaired insulin sensitivity with an alteration of beta-cell function. The consequent hyperglycemia leads to a further increased cardiovascular risk and mortality.Case report: A 16 years old patient was first referred to the Department of Pediatrics in 2014 with accentuated growth since the age of 10. The reason of the first referral was a sport injury (head trauma during playing basketball). Sella MRI depic...

Graves’ orbitopathy (GO) is a common complication of Graves’ disease (GD) which is often responding poorly to therapy. GO may develop before or together with, or during the course of GD. In an individual patient, the development of GO cannot be predicted. We assumed that orbital autoimmune activity is predictable using orbital 99mTc-labelled diethylenetriamine pentaacetic acid (99mTc-DTPA) SPECT. We aimed to determine whether any orbital autoimmune activity can be id...

Aim: Chemerin, a recently discovered adipokine produced by the adipose tissue and liver, along with other atherosclerosis markers, was associated lately with metabolic syndrome and acts as chemoattractant for immune cells may also regulate immune cell properties. Autoimmune Hashimoto’s thyroiditis even with sTSH levels corrected to be within the normal range values may be accompanied by dyslipidemia presenting increased total-C, TG, LDL-C, and Lp(a), all of which are pote...

Background: Hypothyroidism due to autoimmune thyroiditis leads to atherogenic lipid profile and metabolic changes. The formation of advanced glycation end products (AGEs) increases with hyperglycemia, hyperlipidemia and oxidative stress. Degradation of AGEs after AGEs-receptor 1-mediated intracellular uptake and renal clearance of soluble AGEs generated by certain cells like macrophages play a crucial role in the decrement of circulating AGEs level. Chemerin is an adipokine pr...

Background: Advanced glycation end products (AGEs) are heterogenous group of irreversible chemical moieties originated from non-enzymatic glycation and oxidation of proteins, nucleic acids, and lipids. The engagement of AGEs with their chief cellular receptor (RAGE) activates signaling pathways contributing to the progression of chronic diseases like autoimmune thyroiditis, type 2 diabetes mellitus and its complications. Soluble RAGE (sRAGE) prevents AGE-RAGE interaction in a ...